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Robotic reaction platforms

Three Freeslate Junior platforms (UnChained Labs) for a wide range of automated laboratory operations:

Dispensing robot, optimising sampling reactor robot
Dispensing Robot	Optimizing Sampling Reactor Robot	Screening Reactor Robot
Automated dispensing and weighing of solids and liquids Up to 12 solid dispensing source vials for screening multiple solids Positive displacement liquid dispensing Analytical balance (0.1 mg resolution) Integrated camera for inspection of dispensed materials Static minimised by an ioniser In a purge box for inert atmosphere	8 parallel reactors (5-25 mL working volume) with overhead stirring Reaction sampling under pressurised conditions Independent temperature control from –20 to 200 °C Independent gas pressure control from 30 to 145 psi (inert gasses only) Gas selection manifold In a purge box for inert atmosphere	Six independent temperature zones capable of –20 to 180 °C Magnetic tumble stirring in 96 well or vial format Automated liquid dispensing/aspiration Automated preparation of samples for analysis Reactions in vials (96 x 1 mL), jars (<125 mL) and plate formats Pressurised reactor format for screening 48 vial reactions at up to 300 psi

What you get
Optimization of Continuous Variables	Categorical Variable Screening	High-Thoughput Synthesis	Small Scale Kinetics Investigation
Solubility and crystallisation studies Multivariate optimization using Design of Experiments (DoE)	Ligand, solvent and additive screening Full factorial screening 9 heated and stirred plate positions allowing up to 3,000 conditions to be screen in 384 well plates. Sparse arrays for larger experimental space Single or multiple substrate screening	Diverse product sets preparation Automation of individual operations (e.g. dispensing solids) to accelerate your research Testing of multiple reaction conditions in substrate scope Reaction robustness screening Large substrate scope studies	Automated sampling under pressur Streamlined initial kinetics in 8 parallel reactors with independent T and p control Possibility of gas uptake measurement

Next to the Unchained Labs Junior platforms, ROAR offers a range of affordable, low-cost high-throughput equipment:

One Opentrons OT-2 platform for automation of liquid dispensing protocols, using air-displacement pipettes. It can be fitted with 2 of the following pipette heads concurrently:
- Single-channel pipettes (1-20, 20-300 and 100-1000 uL)
- 8-channel pipettes (1-20 and 20-300 uL)
Paradox® and Lumidox® high-throughput plates for photochemical reactions.
- 96-well aluminium block with 1 mL glass inserts for high chemical compatibility
- SBS Plate footprint compatible with robotic platforms (Unchained Labs Juniors and Opentrons) and PolyBLOCKs.
- 4 wavelengths available: blue, green, white and 365 nm UV arrays
One single channel HandyStep™ BRAND™ positive displacement repeater pipette for handheld dispensing of liquid arrays.
- Automatically recognizes tips
- Positive displacement tips for high chemical compatibility
- Volume dispensing range from 1 uL to 50 mL
- Dispense multiple aliquats from a single filling
- Programmable for same volume or varied volume dispense, dispense over time and titration

To find out more about our automation capabilities, contact us at ROAR@imperial.ac.uk

Contact us

The Molecular Sciences Research Hub
Imperial College White City Campus
82 Wood Lane
W12 0BZ London