2020 Publications 

N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects
Wood FA, Howard JP, Finegold JA, Nowbar AN, Thompson DM, Arnold AD, Rajkumar CA, Connolly S, Cegla J, Stride C, Sever P, Norton C, Thom SAM, Shun-Shin MJ, Francis DP. N Engl J Med. 2020 Nov 15. doi: 10.1056/NEJMc2031173. 

Genetic and functional insights into the fractal structure of the heart.
Meyer HV, Dawes TJW, Serrani M, Bai W, Tokarczuk P, Cai J, de Marvao A, Henry A, Lumbers RT, Gierten J, Thumberger T, Wittbrodt J, Ware JS, Rueckert D, Matthews PM, Prasad SK, Costantino ML, Cook SA, Birney E, O'Regan DP. Nature. 2020 Aug;584(7822):589-594. doi: 10.1038/s41586-020-2635-8. Epub 2020 Aug 19. PMID: 32814899.

Repositioning of the global epicentre of non-optimal cholesterol.
NCD Risk Factor Collaboration (NCD-RisC). Nature. 2020 Jun;582(7810):73-77. doi: 10.1038/s41586-020-2338-1. Epub 2020 Jun 3. PMID: 32494083; PMCID: PMC7332422.

A population-based phenome-wide association study of cardiac and aortic structure and function.
Bai W, Suzuki H, Huang J, Francis C, Wang S, Tarroni G, Guitton F, Aung N, Fung K, Petersen SE, Piechnik SK, Neubauer S, Evangelou E, Dehghan A, O'Regan DP, Wilkins MR, Guo Y, Matthews PM, Rueckert D. Nat Med. 2020 Aug 24. doi: 10.1038/s41591-020-1009-y. Epub ahead of print. PMID: 32839619.

Invasive versus non-invasive management of older patients with non-ST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data.
Kaura A, Sterne JAC, Trickey A, Abbott S, Mulla A, Glampson B, Panoulas V, Davies J, Woods K, Omigie J, Shah AD, Channon KM, Weber JN, Thursz MR, Elliott P, Hemingway H, Williams B, Asselbergs FW, O'Sullivan M, Lord GM, Melikian N, Johnson T, Francis DP, Shah AM, Perera D, Kharbanda R, Patel RS, Mayet J. Lancet. 2020 Aug 29;396(10251):623-634. doi: 10.1016/S0140-6736(20)30930-2. PMID: 32861307; PMCID: PMC7456783.

Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome.
Rhodes CJ, Otero-Núñez P, Wharton J, Swietlik EM, Kariotis S, Harbaum L, Dunning MJ, Elinoff JM, Errington N, Thompson AAR, Iremonger J, Coghlan JG, Corris PA, Howard LS, Kiely DG, Church C, Pepke-Zaba J, Toshner M, Wort SJ, Desai AA, Humbert M, Nichols WC, Southgate L, Trégouët DA, Trembath RC, Prokopenko I, Gräf S, Morrell NW, Wang D, Lawrie A, Wilkins MR. Am J Respir Crit Care Med. 2020 Aug 15;202(4):586-594. doi: 10.1164/rccm.202003-0510OC. PMID: 32352834; PMCID: PMC7427383.

Discriminating electrocardiographic responses to His-bundle pacing using machine learning.
Arnold AD, Howard JP, Gopi AA, Chan CP, Ali N, Keene D, Shun-Shin MJ, Ahmad Y, Wright IJ, Ng FS, Linton NWF, Kanagaratnam P, Peters NS, Rueckert D, Francis DP, Whinnett ZI. Cardiovasc Digit Health J. 2020 Jul-Aug;1(1):11-20. doi: 10.1016/j.cvdhj.2020.07.001. PMID: 32954375; PMCID: PMC7484933.

A Mendelian randomization of γ' and total fibrinogen levels on venous thromboembolism and ischemic stroke.
Maners J, Gill D, Pankratz N, Laffan MA, Wolberg AS, de Maat MPM, Ligthart S, Tang W, Ward-Caviness CK, Fornage M, Debette S, Dichgans M, McKnight B, Boerwinkle E, Smith NL, Morrison A, Dehghan A, de Vries PS. Blood. 2020 Jul 28:blood.2019004781. doi: 10.1182/blood.2019004781. Epub ahead of print. PMID: 32722807.

Genetically predicted midlife blood pressure and coronary artery disease risk: Mendelian randomization analysis.
Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans Met al., 2020 Journal of the American Heart Association, Vol: 9, ISSN: 2047-9980