In this section
@article{Braddock:2018:10.1021/acs.orglett.7b03841,
author = {Braddock, DC and Lickiss, P and Rowley, B and Pugh, DC and purnomo and Santhakumar, G and fussell, S},
doi = {10.1021/acs.orglett.7b03841},
journal = {Organic Letters},
pages = {950--953},
title = {Tetramethyl orthosilicate (TMOS) as a reagent for direct amidation of carboxylic acids},
url = {http://dx.doi.org/10.1021/acs.orglett.7b03841},
volume = {20},
year = {2018}
}
TY - JOUR
AB - Tetramethyl orthosilicate (TMOS) is shown to be an effective reagent for direct amidation of aliphatic and aromatic carboxylic acids with amines and anilines. The amide products are obtained in good to quantitative yields in pure form directly after workup without the need for any further purification. A silyl ester as the putative activated intermediate is observed by NMR methods. Amidations on a 1 mol scale are demonstrated with a favorable process mass intensity.
AU - Braddock,DC
AU - Lickiss,P
AU - Rowley,B
AU - Pugh,DC
AU - purnomo
AU - Santhakumar,G
AU - fussell,S
DO - 10.1021/acs.orglett.7b03841
EP - 953
PY - 2018///
SN - 1523-7052
SP - 950
TI - Tetramethyl orthosilicate (TMOS) as a reagent for direct amidation of carboxylic acids
T2 - Organic Letters
UR - http://dx.doi.org/10.1021/acs.orglett.7b03841
UR - https://pubs.acs.org/doi/10.1021/acs.orglett.7b03841
VL - 20
ER -