What is MiroDose?
MiroDose is our second study investigating the physiological changes in the brain related to small vessel disease and the mechanisms behind the changes. MiroDose is an experimental drug study testing the effects of Mirodenafil on the blood flow to the brain. The overall aim is to assess whether it may be an effective medication to lower the risk of stroke and dementia.
What is Mirodenafil:
Mirodenafil is a drug that is lisenced in South Korea, and acts to open up the blood vessels. The drug is currently taken by patients with increased blood pressure in the lungs, or in men with difficulties getting an erection. The medication is widely used and has a well established safety profile, but has not been tested in patients with small vessel disease before.
Participation:
This page covers a general summary of the study, but please read through our downloadable information sheet that contains all the information that must be read through before participating.
If you decide to participate in the study you will take a drug for four weeks. Each week you will have a varying dose of Mirodenafil or a placebo.
You will have a total of five visits to the Imperial Centre of Translational and Experimental Medicine. These are outlined in the downloadable Participant Information Sheet.
Practical information:
What to wear:
- Please wear loose, comfortable clothing, as some mobility tests will involve light movement. If possible, wear clothing with sleeves that can easily roll up for your blood sample.
Location:
NIHR Imperial Clinical Research Facility
Imperial Centre for Translational and Experimental Medicine
Imperial College Healthcare NHS Trust
Hammersmith Hospital Campus,
Du Cane Rd, London W12 0HS
Contact on the day:
- If you have any trouble finding us or need assistance, call 07885610867, and a member of our team will be happy to help.
Important notes:
- You must have read the downloadable information sheet fully before participating.
- All tests are for research purposes only and will not affect your medical care or provide a clinical diagnosis.
- All of the research we publish will be fully anonymised, such that you are not identifiable.
- You do not need to participate in any part of the study you’re not comfortable with.
- You can withdraw from the study at any time without needing to provide a reason.
What will I get for participating?
You will not be paid for the visit itself, but you can be reimbursed for travel expenses and hospital visits that would not happen as part of your normal clinical care.
When will I hear about the research?
We will regularly update the website with our research and you will also receive an annual newsletter from year 2 of the study describing the study progress and any key results or publications.
Thank you for reading about our study and we hope you choose to participate in our research! If you have any questions about this study please contact us here:
Email: mirodose@imperial.ac.uk