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• Journal article
  Yangyuoru PM, DiAntonio M, Ghimire C, Biffi G, Balasubramanian S, Mao Het al., 2015,

  Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G‐Quadruplex

  , Angewandte Chemie, Vol: 127, Pages: 924-927, ISSN: 0044-8249

  <jats:title>Abstract</jats:title><jats:p>In investigating the binding interactions between the human telomeric RNA (TERRA) G‐quadruplex (GQ) and its ligands, it was found that the small molecule carboxypyridostatin (cPDS) and the GQ‐selective antibody BG4 simultaneously bind the TERRA GQ. We previously showed that the overall binding affinity of BG4 for RNA GQs is not significantly affected in the presence of cPDS. However, single‐molecule mechanical unfolding experiments revealed a population (48 %) with substantially increased mechanical and thermodynamic stability. Force‐jump kinetic investigations suggested competitive binding of cPDS and BG4 to the TERRA GQ. Following this, the two bound ligands slowly rearrange, thereby leading to the minor population with increased stability. Given the relevance of G‐quadruplexes in the regulation of biological processes, we anticipate that the unprecedented conformational rearrangement observed in the TERRA‐GQ–ligand complex may inspire new strategies for the selective stabilization of G‐quadruplexes in cells.</jats:p>

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• Journal article
  Yangyuoru PM, Di Antonio M, Ghimire C, Biffi G, Balasubramanian S, Mao Het al., 2015,

  Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex

  , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 54, Pages: 910-913, ISSN: 1433-7851
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  • Citations: 25
• Journal article
  Le DD, Di Antonio M, Chan LKM, Balasubramanian Set al., 2015,

  G-quadruplex ligands exhibit differential G-tetrad selectivity

  , CHEMICAL COMMUNICATIONS, Vol: 51, Pages: 8048-8050, ISSN: 1359-7345
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  • Citations: 70
• Journal article
  Di Antonio M, McLuckie KIE, Balasubramanian S, 2014,

  Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 136, Pages: 5860-5863, ISSN: 0002-7863
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  • Citations: 52
• Journal article
  Biffi G, Di Antonio M, Tannahill D, Balasubramanian Set al., 2014,

  Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

  , NATURE CHEMISTRY, Vol: 6, Pages: 75-80, ISSN: 1755-4330
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  • Citations: 435
• Journal article
  Di Antonio M, 2014,

  Quinone Methides Generation: Applications in Chemical Biology

  , CURRENT ORGANIC CHEMISTRY, Vol: 18, Pages: 2-2, ISSN: 1385-2728
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  • Citations: 2
• Journal article
  McLuckie KIE, Di Antonio M, Zecchini H, Xian J, Caldas C, Krippendorff B-F, Tannahill D, Lowe C, Balasubramanian Set al., 2013,

  G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 135, Pages: 9640-9643, ISSN: 0002-7863
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  • Citations: 103
• Journal article
  Mitchell T, Ramos-Montoya A, Di Antonio M, Murat P, Ohnmacht S, Micco M, Jurmeister S, Fryer L, Balasubramanian S, Neidle S, Neal DEet al., 2013,

  Downregulation of Androgen Receptor Transcription by Promoter G-Quadruplex Stabilization as a Potential Alternative Treatment for Castrate-Resistant Prostate Cancer

  , BIOCHEMISTRY, Vol: 52, Pages: 1429-1436, ISSN: 0006-2960
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  • Citations: 21
• Journal article
  Nikan M, Di Antonio M, Abecassis K, McLuckie K, Balasubramanian Set al., 2013,

  An Acetylene-Bridged 6,8-Purine Dimer as a Fluorescent Switch-On Probe for Parallel G-Quadruplexes

  , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 52, Pages: 1428-1431, ISSN: 1433-7851
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  • Citations: 42
• Journal article
  Murat P, Gormally MV, Sanders D, Di Antonio M, Balasubramanian Set al., 2013,

  Light-mediated <i>in cell</i> downregulation of G-quadruplex-containing genes using a photo-caged ligand

  , CHEMICAL COMMUNICATIONS, Vol: 49, Pages: 8453-8455, ISSN: 1359-7345
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  • Citations: 27
• Journal article
  Di Antonio M, Rodriguez R, Balasubramanian S, 2012,

  Experimental approaches to identify cellular G-quadruplex structures and functions

  , METHODS, Vol: 57, Pages: 84-92, ISSN: 1046-2023
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  • Citations: 38
• Journal article
  Doria F, Nadai M, Folini M, Di Antonio M, Germani L, Percivalle C, Sissi C, Zaffaroni N, Alcaro S, Artese A, Richter SN, Freccero Met al., 2012,

  Hybrid ligand-alkylating agents targeting telomeric G-quadruplex structures

  , ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 10, Pages: 2798-2806, ISSN: 1477-0520
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  • Citations: 90
• Journal article
  Di Antonio M, Biffi G, Mariani A, Raiber E-A, Rodriguez R, Balasubramanian Set al., 2012,

  Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry

  , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 51, Pages: 11073-11078, ISSN: 1433-7851
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  • Citations: 132
• Journal article
  Mueller S, Sanders DA, Di Antonio M, Matsis S, Riou J-F, Rodriguez R, Balasubramanian Set al., 2012,

  Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

  , ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 10, Pages: 6537-6546, ISSN: 1477-0520
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  • Citations: 100
• Journal article
  Nadai M, Doria F, Di Antonio M, Sattin G, Germani L, Percivalle C, Palumbo M, Richter SN, Freccero Met al., 2011,

  Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex

  , BIOCHIMIE, Vol: 93, Pages: 1328-1340, ISSN: 0300-9084
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  • Citations: 80
• Journal article
  Percivalle C, La Rosa A, Verga D, Doria F, Mella M, Palumbo M, Di Antonio M, Freccero Met al., 2011,

  Quinone Methide Generation via Photoinduced Electron Transfer

  , JOURNAL OF ORGANIC CHEMISTRY, Vol: 76, Pages: 3096-3106, ISSN: 0022-3263
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  • Citations: 41
• Journal article
  Verga D, Nadai M, Doria F, Percivalle C, Di Antonio M, Palumbo M, Richter SN, Freccero Met al., 2010,

  Photogeneration and Reactivity of Naphthoquinone Methides as Purine Selective DNA Alkylating Agents

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 132, Pages: 14625-14637, ISSN: 0002-7863
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  • Citations: 90
• Journal article
  Doria F, di Antonio M, Benotti M, Verga D, Freccero Met al., 2009,

  Substituted Heterocyclic Naphthalene Diimides with Unexpected Acidity. Synthesis, Properties, and Reactivity

  , JOURNAL OF ORGANIC CHEMISTRY, Vol: 74, Pages: 8616-8625, ISSN: 0022-3263
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  • Citations: 48
• Journal article
  Di Antonio M, Doria F, Richter SN, Bertipaglia C, Mella M, Sissi C, Palumbo M, Freccero Met al., 2009,

  Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 131, Pages: 13132-13141, ISSN: 0002-7863
  • Author Web Link
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  • Citations: 128
• Journal article
  Di Antonio M, Doria F, Mella M, Merli D, Profumo A, Freccero Met al., 2007,

  Novel naphthalene diimides as activatable precursors of bisalkylating agents, by reduction and base catalysis

  , JOURNAL OF ORGANIC CHEMISTRY, Vol: 72, Pages: 8354-8360, ISSN: 0022-3263
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  • Citations: 33

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