BibTex format
@article{Reiner:2018:10.1056/NEJMoa1716766,
author = {Reiner, RC and Graetz, N and Casey, DC and Troeger, C and Garcia, GM and Mosser, JF and Deshpande, A and Swartz, SJ and Ray, SE and Blacker, BF and Rao, PC and Osgood-Zimmerman, A and Burstein, R and Pigott, DM and Davis, IM and Letourneau, ID and Earl, L and Ross, JM and Khalil, IA and Farag, TH and Brady, OJ and Kraemer, MUG and Smith, DL and Bhatt, S and Weiss, DJ and Gething, PW and Kassebaum, NJ and Mokdad, AH and Murray, CJL and Hay, SI},
doi = {10.1056/NEJMoa1716766},
journal = {New England Journal of Medicine},
pages = {1128--1138},
title = {Variation in Childhood Diarrheal Morbidity and Mortality in Africa, 2000-2015},
url = {http://dx.doi.org/10.1056/NEJMoa1716766},
volume = {379},
year = {2018}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundDiarrheal diseases are the third leading cause of disease and death in children younger than 5 years of age in Africa and were responsible for an estimated 30 million cases of severe diarrhea (95% credible interval, 27 million to 33 million) and 330,000 deaths (95% credible interval, 270,000 to 380,000) in 2015. The development of targeted approaches to address this burden has been hampered by a paucity of comprehensive, fine-scale estimates of diarrhea-related disease and death among and within countries.MethodsWe produced annual estimates of the prevalence and incidence of diarrhea and diarrhea-related mortality with high geographic detail (5 km2) across Africa from 2000 through 2015. Estimates were created with the use of Bayesian geostatistical techniques and were calibrated to the results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016.ResultsThe results revealed geographic inequality with regard to diarrhea risk in Africa. Of the estimated 330,000 childhood deaths that were attributable to diarrhea in 2015, more than 50% occurred in 55 of the 782 first-level administrative subdivisions (e.g., states). In 2015, mortality rates among first-level administrative subdivisions in Nigeria differed by up to a factor of 6. The case fatality rates were highly varied at the national level across Africa, with the highest values observed in Benin, Lesotho, Mali, Nigeria, and Sierra Leone.ConclusionsOur findings showed concentrated areas of diarrheal disease and diarrhea-related death in countries that had a consistently high burden as well as in countries that had considerable national-level reductions in diarrhea burden. (Funded by the Bill and Melinda Gates Foundation.)
AU - Reiner,RC
AU - Graetz,N
AU - Casey,DC
AU - Troeger,C
AU - Garcia,GM
AU - Mosser,JF
AU - Deshpande,A
AU - Swartz,SJ
AU - Ray,SE
AU - Blacker,BF
AU - Rao,PC
AU - Osgood-Zimmerman,A
AU - Burstein,R
AU - Pigott,DM
AU - Davis,IM
AU - Letourneau,ID
AU - Earl,L
AU - Ross,JM
AU - Khalil,IA
AU - Farag,TH
AU - Brady,OJ
AU - Kraemer,MUG
AU - Smith,DL
AU - Bhatt,S
AU - Weiss,DJ
AU - Gething,PW
AU - Kassebaum,NJ
AU - Mokdad,AH
AU - Murray,CJL
AU - Hay,SI
DO - 10.1056/NEJMoa1716766
EP - 1138
PY - 2018///
SN - 0028-4793
SP - 1128
TI - Variation in Childhood Diarrheal Morbidity and Mortality in Africa, 2000-2015
T2 - New England Journal of Medicine
UR - http://dx.doi.org/10.1056/NEJMoa1716766
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445020900007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL - 379
ER -