BibTex format
@unpublished{Neumann:2020:10.1101/2020.06.04.20121061,
author = {Neumann, A and Nolte, IM and Pappa, I and Ahluwalia, TS and Pettersson, E and Rodriguez, A and Whitehouse, A and van, Beijsterveldt CEM and Benyamin, B and Hammerschlag, AR and Helmer, Q and Karhunen, V and Krapohl, E and Lu, Y and van, der Most PJ and Palviainen, T and Pourcain, BS and Seppälä, I and Suarez, A and Vilor-Tejedor, N and Tiesler, CMT and Wang, C and Wills, A and Zhou, A and Alemany, S and Bisgaard, H and Bønnelykke, K and Davies, GE and Hakulinen, C and Henders, AK and Hyppönen, E and Stokholm, J and Bartels, M and Hottenga, J-J and Heinrich, J and Hewitt, J and Keltikangas-Järvinen, L and Korhonen, T and Kaprio, J and Lahti, J and Lahti-Pulkkinen, M and Lehtimäki, T and Middeldorp, CM and Najman, JM and Pennell, C and Power, C and Oldehinkel, AJ and Plomin, R and Räikkönen, K and Raitakari, OT and Rimfeld, K and Sass, L and Snieder, H and Standl, M and Sunyer, J and Williams, GM and Bakermans-Kranenburg, MJ and Boomsma, DI and van, IJzendoorn MH and Hartman, CA and Tiem},
doi = {10.1101/2020.06.04.20121061},
title = {A genome-wide association study of total child psychiatric problems scores},
url = {http://dx.doi.org/10.1101/2020.06.04.20121061},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - UNPB
AB - <jats:title>ABSTRACT</jats:title> <jats:p> Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium. The SNP heritability of total psychiatric problems was 5.4% (SE=0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of <jats:italic>SBF2</jats:italic> , a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total psychiatric problem score were shared with known genetic variants for common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (r <jats:sub>G</jats:sub> > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (r <jats:sub>G</jats:sub> < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation of with intelligence, educational attainment, wellbeing, smoking, and body fat (r <jats:sub>G</jats:sub> > 0.29).The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between psychiatric disorders and related
AU - Neumann,A
AU - Nolte,IM
AU - Pappa,I
AU - Ahluwalia,TS
AU - Pettersson,E
AU - Rodriguez,A
AU - Whitehouse,A
AU - van,Beijsterveldt CEM
AU - Benyamin,B
AU - Hammerschlag,AR
AU - Helmer,Q
AU - Karhunen,V
AU - Krapohl,E
AU - Lu,Y
AU - van,der Most PJ
AU - Palviainen,T
AU - Pourcain,BS
AU - Seppälä,I
AU - Suarez,A
AU - Vilor-Tejedor,N
AU - Tiesler,CMT
AU - Wang,C
AU - Wills,A
AU - Zhou,A
AU - Alemany,S
AU - Bisgaard,H
AU - Bønnelykke,K
AU - Davies,GE
AU - Hakulinen,C
AU - Henders,AK
AU - Hyppönen,E
AU - Stokholm,J
AU - Bartels,M
AU - Hottenga,J-J
AU - Heinrich,J
AU - Hewitt,J
AU - Keltikangas-Järvinen,L
AU - Korhonen,T
AU - Kaprio,J
AU - Lahti,J
AU - Lahti-Pulkkinen,M
AU - Lehtimäki,T
AU - Middeldorp,CM
AU - Najman,JM
AU - Pennell,C
AU - Power,C
AU - Oldehinkel,AJ
AU - Plomin,R
AU - Räikkönen,K
AU - Raitakari,OT
AU - Rimfeld,K
AU - Sass,L
AU - Snieder,H
AU - Standl,M
AU - Sunyer,J
AU - Williams,GM
AU - Bakermans-Kranenburg,MJ
AU - Boomsma,DI
AU - van,IJzendoorn MH
AU - Hartman,CA
AU - Tiemeier,H
DO - 10.1101/2020.06.04.20121061
PY - 2020///
TI - A genome-wide association study of total child psychiatric problems scores
UR - http://dx.doi.org/10.1101/2020.06.04.20121061
UR - https://doi.org/10.1101/2020.06.04.20121061
ER -