BibTex format
@article{Ip:2021:10.1038/s41398-021-01480-x,
author = {Ip, HF and van, der Laan CM and Krapohl, EML and Brikell, I and Sanchez-Mora, C and Nolte, IM and St, Pourcain B and Bolhuis, K and Palviainen, T and Zafarmand, H and Colodro-Conde, L and Gordon, S and Zayats, T and Aliev, F and Jiang, C and Wang, CA and Saunders, G and Karhunen, V and Hammerschlag, AR and Adkins, DE and Border, R and Peterson, RE and Prinz, JA and Thiering, E and Seppala, I and Vilor-Tejedor, N and Ahluwalia, TS and Day, FR and Hottenga, J-J and Allegrini, AG and Rimfeld, K and Chen, Q and Lu, Y and Martin, J and Soler, Artigas M and Rovira, P and Bosch, R and Espanol, G and Ramos, Quiroga JA and Neumann, A and Ensink, J and Grasby, K and Morosoli, JJ and Tong, X and Marrington, S and Middeldorp, C and Scott, JG and Vinkhuyzen, A and Shabalin, AA and Corley, R and Evans, LM and Sugden, K and Alemany, S and Sass, L and Vinding, R and Ruth, K and Tyrrell, J and Davies, GE and Ehli, EA and Hagenbeek, FA and De, Zeeuw E and Van, Beijsterveldt TCEM and Larsson, H and Snied},
doi = {10.1038/s41398-021-01480-x},
journal = {Translational Psychiatry},
pages = {1--9},
title = {Genetic association study of childhood aggression across raters, instruments, and age},
url = {http://dx.doi.org/10.1038/s41398-021-01480-x},
volume = {11},
year = {2021}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE = 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three significant genes: ST3GAL3 (P = 1.6E–06), PCDH7 (P = 2.0E–06), and IPO13 (P = 2.5E–06). All three genes have previously been associated with educational traits. Polygenic scores based on our GWAMA significantly predicted aggression in a holdout sample of children (variance explained = 0.44%) and in retrospectively assessed childhood aggression (variance explained = 0.20%). Genetic correlations (rg) among rater-specific assessment of AGG ranged from rg = 0.46 between self- and teacher-assessment to rg = 0.81 between mother- and teacher-assessment. We obtained moderate-to-strong rgs with selected phenotypes from multiple domains, but hardly with any of the classical biomarkers thought to be associated with AGG. Significant genetic correlations were observed with most psychiatric and psychological traits (range
AU - Ip,HF
AU - van,der Laan CM
AU - Krapohl,EML
AU - Brikell,I
AU - Sanchez-Mora,C
AU - Nolte,IM
AU - St,Pourcain B
AU - Bolhuis,K
AU - Palviainen,T
AU - Zafarmand,H
AU - Colodro-Conde,L
AU - Gordon,S
AU - Zayats,T
AU - Aliev,F
AU - Jiang,C
AU - Wang,CA
AU - Saunders,G
AU - Karhunen,V
AU - Hammerschlag,AR
AU - Adkins,DE
AU - Border,R
AU - Peterson,RE
AU - Prinz,JA
AU - Thiering,E
AU - Seppala,I
AU - Vilor-Tejedor,N
AU - Ahluwalia,TS
AU - Day,FR
AU - Hottenga,J-J
AU - Allegrini,AG
AU - Rimfeld,K
AU - Chen,Q
AU - Lu,Y
AU - Martin,J
AU - Soler,Artigas M
AU - Rovira,P
AU - Bosch,R
AU - Espanol,G
AU - Ramos,Quiroga JA
AU - Neumann,A
AU - Ensink,J
AU - Grasby,K
AU - Morosoli,JJ
AU - Tong,X
AU - Marrington,S
AU - Middeldorp,C
AU - Scott,JG
AU - Vinkhuyzen,A
AU - Shabalin,AA
AU - Corley,R
AU - Evans,LM
AU - Sugden,K
AU - Alemany,S
AU - Sass,L
AU - Vinding,R
AU - Ruth,K
AU - Tyrrell,J
AU - Davies,GE
AU - Ehli,EA
AU - Hagenbeek,FA
AU - De,Zeeuw E
AU - Van,Beijsterveldt TCEM
AU - Larsson,H
AU - Snieder,H
AU - Verhulst,FC
AU - Amin,N
AU - Whipp,AM
AU - Korhonen,T
AU - Vuoksimaa,E
AU - Rose,RJ
AU - Uitterlinden,AG
AU - Heath,AC
AU - Madden,P
AU - Haavik,J
AU - Harris,JR
AU - Helgeland,O
AU - Johansson,S
AU - Knudsen,GPS
AU - Njolstad,PR
AU - Lu,Q
AU - Rodriguez,A
AU - Henders,AK
AU - Mamun,A
AU - Najman,JM
AU - Brown,S
AU - Hopfer,C
AU - Krauter,K
AU - Reynolds,C
AU - Smolen,A
AU - Stallings,M
AU - Wadsworth,S
AU - Wall,TL
AU - Silberg,JL
AU - Miller,A
AU - Keltikangas-Jarvinen,L
AU - Hakulinen,C
AU - Pulkki-Raback,L
AU - Havdahl,A
AU - Magnus,P
AU - Raitakari,OT
AU - Perry,JRB
AU - Llop,S
AU - Lopez-Espinosa,M-J
AU - Bonnelykke,K
AU - Bisgaard,H
AU - Sunyer,J
AU - Lehtimaki,T
AU - Arseneault,L
AU - Standl,M
AU - Heinrich,J
AU - Boden,J
AU - Pearson,J
AU - Horwood,LJ
AU - Kennedy,M
AU - Poulton,R
AU - Eaves,LJ
AU - Maes,HH
AU - Hewitt,J
AU - Copeland,WE
AU - Costello,EJ
AU - Williams,GM
AU - Wray,N
AU - Jarvelin,M-R
AU - McGue,M
AU - Iacono,W
AU - Caspi,A
AU - Moffitt,TE
AU - Whitehouse,A
AU - Pennell,CE
AU - Klump,KL
AU - Burt,SA
AU - Dick,DM
AU - Reichborn-Kjennerud,T
AU - Martin,NG
AU - Medland,SE
AU - Vrijkotte,T
AU - Kaprio,J
AU - Tiemeier,H
AU - Davey,Smith G
AU - Hartman,CA
AU - Oldehinkel,AJ
AU - Casas,M
AU - Ribases,M
AU - Lichtenstein,P
AU - Lundstrom,S
AU - Plomin,R
AU - Bartels,M
AU - Nivard,MG
AU - Boomsma,DI
DO - 10.1038/s41398-021-01480-x
EP - 9
PY - 2021///
SN - 2158-3188
SP - 1
TI - Genetic association study of childhood aggression across raters, instruments, and age
T2 - Translational Psychiatry
UR - http://dx.doi.org/10.1038/s41398-021-01480-x
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000679719900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://www.nature.com/articles/s41398-021-01480-x
VL - 11
ER -