BibTex format
@article{van:2025:10.1038/s41588-025-02295-y,
author = {van, der Laan CM and Ip, HF and Schipper, M and Hottenga, J-J and St, Pourcain B and Zayats, T and Pool, R and Krapohl, EML and Brikell, I and Soler, Artigas M and Cabana-Domínguez, J and Llonga, N and Nolte, IM and Bolhuis, K and Palviainen, T and Zafarmand, H and Gordon, S and Aliev, F and Burt, SA and Wang, CA and Saunders, G and Karhunen, V and Adkins, DE and Border, R and Peterson, RE and Prinz, JA and Thiering, E and Vilor-Tejedor, N and Ahluwalia, TS and Allegrini, A and Rimfeld, K and Chen, Q and Lu, Y and Martin, J and Bosch, R and Ramos-Quiroga, JA and Neumann, A and Ensink, J and Grasby, KL and Morosoli, JJ and Tong, X and Marrington, S and Scott, JG and Shabalin, AA and Corley, R and Evans, LM and Sugden, K and Alemany, S and Sass, L and Vinding, R and Ehli, EA and Hagenbeek, FA and Derks, EM and Larsson, H and Snieder, H and Cecil, C and Whipp, AM and Korhonen, T and Vuoksimaa, E and Rose, RJ and Uitterlinden, AG and Haavik, J and Harris, JR and Helgeland, Ø and Johansson,},
doi = {10.1038/s41588-025-02295-y},
journal = {Nat Genet},
pages = {2427--2435},
title = {Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes.},
url = {http://dx.doi.org/10.1038/s41588-025-02295-y},
volume = {57},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - We performed a genome-wide association meta-analysis (GWAMA) of 290,134 attention-deficit/hyperactivity disorder (ADHD) symptom measures of 70,953 unique individuals from multiple raters, ages and instruments (ADHDSYMP). Next, we meta-analyzed the results with a study of ADHD diagnosis (ADHDOVERALL). ADHDSYMP returned no genome-wide significant variants. We show that the combined ADHDOVERALL GWAMA identified 39 independent loci, of which 17 were new. Using a recently developed gene-mapping method, Fine-mapped Locus Assessment Model of Effector genes, we identified 22 potential ADHD effector genes implicating several new biological processes and pathways. Moderate negative genetic correlations (rg < -0.40) were observed with multiple cognitive traits. In three cohorts, polygenic scores (PGSs) based on ADHDOVERALL outperformed PGSs based on ADHD symptoms and diagnosis alone. Our findings support the notion that clinical ADHD is at the extreme end of a continuous liability that is indexed by ADHD symptoms. We show that including ADHD symptom counts helps to identify new genes implicated in ADHD.
AU - van,der Laan CM
AU - Ip,HF
AU - Schipper,M
AU - Hottenga,J-J
AU - St,Pourcain B
AU - Zayats,T
AU - Pool,R
AU - Krapohl,EML
AU - Brikell,I
AU - Soler,Artigas M
AU - Cabana-Domínguez,J
AU - Llonga,N
AU - Nolte,IM
AU - Bolhuis,K
AU - Palviainen,T
AU - Zafarmand,H
AU - Gordon,S
AU - Aliev,F
AU - Burt,SA
AU - Wang,CA
AU - Saunders,G
AU - Karhunen,V
AU - Adkins,DE
AU - Border,R
AU - Peterson,RE
AU - Prinz,JA
AU - Thiering,E
AU - Vilor-Tejedor,N
AU - Ahluwalia,TS
AU - Allegrini,A
AU - Rimfeld,K
AU - Chen,Q
AU - Lu,Y
AU - Martin,J
AU - Bosch,R
AU - Ramos-Quiroga,JA
AU - Neumann,A
AU - Ensink,J
AU - Grasby,KL
AU - Morosoli,JJ
AU - Tong,X
AU - Marrington,S
AU - Scott,JG
AU - Shabalin,AA
AU - Corley,R
AU - Evans,LM
AU - Sugden,K
AU - Alemany,S
AU - Sass,L
AU - Vinding,R
AU - Ehli,EA
AU - Hagenbeek,FA
AU - Derks,EM
AU - Larsson,H
AU - Snieder,H
AU - Cecil,C
AU - Whipp,AM
AU - Korhonen,T
AU - Vuoksimaa,E
AU - Rose,RJ
AU - Uitterlinden,AG
AU - Haavik,J
AU - Harris,JR
AU - Helgeland,Ø
AU - Johansson,S
AU - Knudsen,GPS
AU - Njolstad,PR
AU - Lu,Q
AU - Rodriguez,A
AU - Henders,AK
AU - Mamun,A
AU - Najman,JM
AU - Brown,S
AU - Hopfer,C
AU - Krauter,K
AU - Reynolds,CA
AU - Smolen,A
AU - Stallings,M
AU - Wadsworth,S
AU - Wall,TL
AU - Eaves,L
AU - Silberg,JL
AU - Miller,A
AU - Havdahl,A
AU - Llop,S
AU - Lopez-Espinosa,M-J
AU - Bønnelykke,K
AU - Sunyer,J
AU - Arseneault,L
AU - Standl,M
AU - Heinrich,J
AU - Boden,J
AU - Pearson,J
AU - Horwood,J
AU - Kennedy,M
AU - Poulton,R
AU - Maes,HH
AU - Hewitt,J
AU - Copeland,WE
AU - Middeldorp,CM
AU - Williams,GM
AU - Wray,N
AU - Järvelin,M-R
AU - McGue,M
AU - Iacono,W
AU - Caspi,A
AU - Moffitt,TE
AU - Whitehouse,AJO
AU - Pennell,CE
AU - Klump,KL
AU - Jiang,C
AU - Dick,DM
AU - Reichborn-Kjennerud,T
AU - Martin,NG
AU - Medland,SE
AU - Vrijkotte,T
AU - Kaprio,J
AU - Tiemeier,H
AU - Davey,Smith G
AU - Hartman,CA
AU - Oldehinkel,AJ
AU - Casas,M
AU - Ribasés,M
AU - Lichtenstein,P
AU - Lundström,S
AU - Plomin,R
AU - Bartels,M
AU - Nivard,MG
AU - Boomsma,DI
DO - 10.1038/s41588-025-02295-y
EP - 2435
PY - 2025///
SP - 2427
TI - Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes.
T2 - Nat Genet
UR - http://dx.doi.org/10.1038/s41588-025-02295-y
UR - https://www.ncbi.nlm.nih.gov/pubmed/40962958
VL - 57
ER -