BibTex format
@article{St:2014:10.1038/ncomms5831,
author = {St, Pourcain B and Cents, RAM and Whitehouse, AJO and Haworth, CMA and Davis, OSP and O'Reilly, PF and Roulstone, S and Wren, Y and Ang, QW and Velders, FP and Evans, DM and Kemp, JP and Warrington, NM and Miller, L and Timpson, NJ and Ring, SM and Verhulst, FC and Hofman, A and Rivadeneira, F and Meaburn, EL and Price, TS and Dale, PS and Pillas, D and Yliherva, A and Rodriguez, A and Golding, J and Jaddoe, VWV and Jarvelin, M-R and Plomin, R and Pennell, CE and Tiemeier, H and Smith, GD},
doi = {10.1038/ncomms5831},
journal = {Nature Communications},
title = {Common variation near ROBO2 is associated with expressive vocabulary in infancy},
url = {http://dx.doi.org/10.1038/ncomms5831},
volume = {5},
year = {2014}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the EArly Genetics and Lifecourse Epidemiology consortium, analysing an early (15–18 months, ‘one-word stage’, NTotal=8,889) and a later (24–30 months, ‘two-word stage’, NTotal=10,819) phase of language acquisition. For the early phase, one single-nucleotide polymorphism (rs7642482) at 3p12.3 near ROBO2, encoding a conserved axon-binding receptor, reaches the genome-wide significance level (P=1.3 × 10−8) in the combined sample. This association links language-related common genetic variation in the general population to a potential autism susceptibility locus and a linkage region for dyslexia, speech-sound disorder and reading. The contribution of common genetic influences is, although modest, supported by genome-wide complex trait analysis (meta-GCTA h215–18-months=0.13, meta-GCTA h224–30-months=0.14) and in concordance with additional twin analysis (5,733 pairs of European descent, h224-months=0.20).
AU - St,Pourcain B
AU - Cents,RAM
AU - Whitehouse,AJO
AU - Haworth,CMA
AU - Davis,OSP
AU - O'Reilly,PF
AU - Roulstone,S
AU - Wren,Y
AU - Ang,QW
AU - Velders,FP
AU - Evans,DM
AU - Kemp,JP
AU - Warrington,NM
AU - Miller,L
AU - Timpson,NJ
AU - Ring,SM
AU - Verhulst,FC
AU - Hofman,A
AU - Rivadeneira,F
AU - Meaburn,EL
AU - Price,TS
AU - Dale,PS
AU - Pillas,D
AU - Yliherva,A
AU - Rodriguez,A
AU - Golding,J
AU - Jaddoe,VWV
AU - Jarvelin,M-R
AU - Plomin,R
AU - Pennell,CE
AU - Tiemeier,H
AU - Smith,GD
DO - 10.1038/ncomms5831
PY - 2014///
SN - 2041-1723
TI - Common variation near ROBO2 is associated with expressive vocabulary in infancy
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/ncomms5831
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342929300002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL - 5
ER -