Citation

BibTex format

@inproceedings{Moore:2016:10.1183/13993003.congress-2016.PA1126,
author = {Moore, EA and Chatzidiakou, L and Kuku, M-O and Jones, RL and Smeeth, L and Beevers, S and Kelly, FJ and Barratt, B and Quint, JK},
doi = {10.1183/13993003.congress-2016.PA1126},
pages = {PA1126--PA1126},
publisher = {European Respiratory Society},
title = {Global associations between air pollutants and Chronic Obstructive Pulmonary Disease (COPD) exacerbations: a systematic review},
url = {http://dx.doi.org/10.1183/13993003.congress-2016.PA1126},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Background: COPD exacerbations (AECOPD) affect lung function decline and quality of life. The effect of exposure to different air pollutants on AECOPD is unclear.Aim: We systematically reviewed the literature examining associations between air pollutants and hospital admissions for AECOPD.Methods: MEDLINE, EMBASE, BIOSIS & Science Citation Index were searched until September 2015. Inclusion criteria focused on studies presenting solely a COPD outcome defined by hospital admissions, and a measure of gaseous air pollutants and particle fractions. The association between each pollutant with COPD admissions was investigated in meta-analyses using random-effects models. Analyses were stratified by geographical clusters to investigate the evidence worldwide.Results: 46 studies were included and results showed marginal positive associations. The number of included studies was small with high heterogeneity between them and there was evidence of small-study bias. Geographical clustering of the effects of pollution on COPD hospital admissions was evident and reduced heterogeneity significantly. The most consistent association was between a 1mg/m3 increase in carbon monoxide levels with COPD related admissions; Odds Ratio: 1.2 (95%CI: 1.01-1.03).Conclusions: There is mixed evidence on the effects of pollution on AECOPD. Limitations of previous studies include the low spatio-temporal resolution of pollutants, inadequate control for confounding factors, and the use of aggregated health data that ignore personal characteristics. The need for personal exposure monitoring in a large number of geographical locations is evident.
AU  - Moore,EA
AU  - Chatzidiakou,L
AU  - Kuku,M-O
AU  - Jones,RL
AU  - Smeeth,L
AU  - Beevers,S
AU  - Kelly,FJ
AU  - Barratt,B
AU  - Quint,JK
DO  - 10.1183/13993003.congress-2016.PA1126
EP  - 1126
PB  - European Respiratory Society
PY  - 2016///
SN  - 0903-1936
SP  - 1126
TI  - Global associations between air pollutants and Chronic Obstructive Pulmonary Disease (COPD) exacerbations: a systematic review
UR  - http://dx.doi.org/10.1183/13993003.congress-2016.PA1126
ER  -
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