Dr Alain Tedgui from the Paris Cardiovascular Research Center, INSERM will be delivering a seminar a Imperial College on 10th September. His presentation is entitled ‘Role of Pathogenic and Regulatory Adaptive Immunity in Atherosclerosis’, and will take place at 5.30pm in the Pippard Lecture Theatre, located on the 5th floor of the Sherfield Building at South Kensington.
Dr Tedgui obtained his PhD in Fluid Mechanics, then worked on the mechanisms of macromolecule transport in the arterial wall that play a major role in atherogenesis, in the Physiological Flow Studies Unit at Imperial College. After his post-doctoral fellowship he joined the French Institute of Health and Medical Research (INSERM) in 1983. He headed an INSERM laboratory at the Paris Hospital Lariboisière from 2000 to 2004.
His current primary research is aimed at elucidating the role of apoptosis and inflammation in atherosclerosis. His group has shown that apoptotic death leading to the generation of apoptotic microparticles is the major determinant of the thrombogenicity of the lipid core. More recently, he bridged the interface between vascular biology and immunology in showing that a subset of immune cells, CD4+CD25+ regulatory T cells, limits the development of atherosclerosis and can be used as a promising anti-atherosclerotic strategy to curtail inflammation. He is the European Editor of Arteriosclerosis Thrombosis and Vascular Biology.