IMSE Webinar Series
Challenges in Antimicrobial Resistance
The challenge that will be discussed in this session is:
Microchip Technology enabling rapid diagnostics for infectious diseases: From AMR to COVID-19
Join us for this informal webinar with Dr Pantelis Georgiou. There will be an opportunity for question and answer after the presentation. To join this webinar you must register in advance and you will be emailed the joining instructions for the webinar.
In the last decade, we have seen a convergence of microelectronics into the world of healthcare providing novel solutions for early detection, diagnosis and therapy of disease. This has been made possible due to the emergence of CMOS technology, allowing fabrication of advanced systems with complete integration of sensors, instrumentation and processing, enabling design of miniaturised medical devices which operate with low-power. This has been specifically beneficial for the application areas of DNA based diagnostics and full genome sequencing, where the implementation of chemical sensors known as Ion-Sensitive Field Effect Transistors (ISFETs) directly in CMOS has enabled the design of large-scale arrays of millions of sensors that can conduct in-parallel detection of nucleic acids. Furthermore, the scaling of CMOS with Moore’s law and the integration capability with microfluidics has enabled the creation of hand-held and portable rapid diagnostic systems for infectious diseases.
In this talk, Dr Georgiou presents how his lab is advancing the areas of DNA and RNA detection for rapid diagnostics of infectious diseases and AMR through the design of CMOS based Lab-on-Chip systems using ISFETs. He will showcase Lacewing, their latest handheld diagnostic system which is able to rapidly identify bacterial and viral infections in under 30 minutes, communicating results in real-time to the cloud for epidemiological surveillance. Results from our latest trials for detection of Malaria and bacterial resistant infections will be shown in addition to our most recent efforts in tackling the COVID-19 outbreak.
Dr Pantelis Georgiou
Faculty of Engineering, Department of Electrical and Electronic Engineering
Pantelis Georgiou currently holds the position of Reader (Associate Professor) at Imperial College London within the Department of Electrical and Electronic Engineering. He is the head of the Bio-inspired Metabolic Technology Laboratory in the Centre for Bio-Inspired Technology; a multi-disciplinary group that invents, develops and demonstrates advanced micro-devices to meet global challenges in biomedical science and healthcare. His research includes ultra-low power micro-electronics, bio-inspired circuits and systems, lab-on-chip technology and application of micro-electronic technology to create novel medical devices. Application areas of his research include new technologies for treatment of diabetes such as the artificial pancreas, novel Lab-on-Chip technology for genomics and diagnostics targeted towards infectious disease and antimicrobial resistance (AMR), and wearable technologies for rehabilitation of chronic conditions.
Dr. Georgiou graduated with a 1st Class Honours MEng Degree in Electrical and Electronic Engineering in 2004 and Ph.D. degree in 2008 both from Imperial College London. He then joined the Institute of Biomedical Engineering as Research Associate until 2010, when he was appointed Head of the Bio-inspired Metabolic Technology Laboratory. In 2011, he joined the Department of Electrical & Electronic Engineering, where he currently holds an academic faculty position. He conducted pioneering work on the silicon beta cell and is now leading the project forward to the development of the first bio-inspired artificial pancreas for treatment of Type I diabetes. In addition to this, he made significant contributions to the development of integrated chemical-sensing systems in CMOS. He has pioneered the development of the Ion-Sensitive Field Effect Transistor, an integrated pH sensor which is currently being used in next generation DNA sequencing machines, demonstrating for the first time its use in low-power weak-inversion, and its capability in a multimodal sensing array for Lab-on-Chip applications. Dr. Georgiou is a senior member of the IEEE and IET and serves on the BioCAS and Sensory Systems technical committees of the IEEE CAS Society. He is an associate editor of the IEEE Sensors and TBioCAS journals. He is also the CAS representative on the IEEE sensors council. In 2013 he was awarded the IET Mike Sergeant Achievement Medal for his outstanding contributions to engineering and development of the bio-inspired artificial pancreas. In 2017, he was also awarded the IEEE Sensors Council Technical Achievement award. He is an IEEE Distinguished Lecturer in Circuits and Systems.
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More webinars in the Antimicrobial Resistance Webinar series:
- 30 April 14.00 Viral Interferon Inhibiting Proteins and Self-Amplifying RNA Vaccines presented by Dr Anna Blakney
- 7 May 14.00 Studying Ratcheting Complexity in Evolution presented by Dr Morgan Beeby
- 14 May 14.00 Engineering Smart Surfaces: From The Laboratory Towards Real Life Use presented by Professor Nicholas Harrison, Professor Daryl Williams and Dr Gerald Larrouy-Maumus
- 21 May 14.00 How Artificial Gut Systems Show How Gut Microbiota Protect from Infection presented by Dr Julie McDonald
- 28 May 14.00 Synthetic Biology in Yeast for Sensing Pathogens Secreting Antimicrobials presented by Professor Tom Ellis
- 11 June 14.00 An Emerging Low-Cost Bacteria Adhesive Surfaces presented by Dr Pavani Cherukupally
- 18 June 16.00 Low Cost Polymeric Materials with Anti-Microbial Properties presented by Professor Daryl Williams
- 25 June 14.00 Lymphatic System Transport and Vaccine Adjuvants presented by Professor James Moore.
- 2 July 14.00 Microchip Technology enabling rapid diagnostics : from AMR – COVID-19 presented by Dr Pantelis Georgiou
For more information about IMSE involvement with surfaces to combat Antimicrobial Resistance please read our briefing paper Smart Surfaces to Tackle Infection and Anti Microbial Resistance