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Centre for Neurotechnology seminar from Fei Chen

Core Member, Broad Institute
Assistant Professor, Harvard Stem Cell and Regenerative Biology

Talk title: Novel Tools for Spatial and Temporal Genomics

Abstract: The precise spatial localization of molecular signals within tissues richly informs the mechanisms of tissue formation and function. Here, we’ll introduce Slide-seq, a technology which enables transcriptome-wide measurements with near-single cell spatial resolution. We’ll describe recent experimental and computational advances to enable Slide-seq in biological contexts in biological contexts where high detection sensitivity is important. More broadly, we’ll discuss the promise and challenges of spatial transcriptomics for tissue genomics. Lastly, we’ll touch upon novel molecular recording technologies, which allows recording of the absolute time dynamics of gene expression in live systems into DNA sequences.

Bio: Fei Chen is a core institute member at the Broad Institute of MIT and Harvard and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University. During the course of his doctoral research, Chen co-invented Expansion Microscopy, a breakthrough technique that allows for super-resolution imaging of biological samples with conventional light microscopes. As an independent Fellow at the Broad Institute, he led a group which bridged microscopy with next generation sequencing through in situ sequencing and Slide-seq technologies. In his current group, he continues to pioneer novel molecular and microscopy tools to uniquely illuminate biological pathways and function.

Chen was an Axline scholar at the California Institute of Technology and graduated with a bachelor’s degree in electrical engineering. He obtained his Ph.D. in biological engineering from the Massachusetts Institute of Technology, where he was funded by the National Science Foundation Graduate Research Fellowship and the MIT Viterbi and Poitras Fellowships. Following his graduate studies, Chen was a fellow in the Schmidt Fellows program at the Broad. His awards include the National Institutes of Health Director’s Early Independence Award and the Allen Distinguished Investigator Award.

The Chen Lab


The seminar will take place via Microsoft Teams. Advance registration is required. A link and instructions on how to access the event are provided in your registration confirmation email and a reminder will be sent before the event.

There is no need to download the Microsoft Teams app if accessing the seminar via desktop or laptop as you can join via a browser, however if using a mobile device, you will need to download the Teams app in advance.

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