Talk title: SYNTHETIC DEVELOPMENTAL BIOLOGY: Cross-species comparison and manipulation of organoids
Abstract: While mechanisms of embryonic development are well conserved among mammals, the progression speed tends to be slower in larger species. To study differences in time between species, my group uses in vitro systems. We have recently recapitulated the segmentation clock, oscillatory gene expression during early development, from human and mouse pluripotent stem cells. The oscillation period of the human segmentation clock is 5-6 hours, while the mouse period is 2-3 hours. We found that this period difference between species stems from slower biochemical reactions in human cells, including slower protein degradation and longer delays in gene expression processes. Now we are extending this approach of cross-species comparison to other mammalian species, including cows and rhinos, and other developmental processes. In parallel, we develop genetic tools to manipulate developmental processes and organoids.
Speaker biography: Miki Ebisuya did her under graduate and PhD research at Kyoto University, Japan. After getting her PhD in 2008, she became a group leader at Kyoto University in 2009. Her lab moved to RIKEN in 2013, and then moved again to EMBL Barcelona, Spain, in 2018. The research interest of her group is to reconstitute developmental mechanisms in cell culture.