Please join us online on Wednesday 27th October from 12:00 – 13:00 at the CRI Interface Section External Seminar Series.

We will have an exciting talk from Assistant Professor Jose Javier Bravo-Cordero on ‘High-resolution intravital microscopy reveals the plastic behavior of dormant cancer cells and their niches’.

Dr Bravo-Cordero is trained as a cell biologist and molecular biologist. During his postdoc at the Albert Einstein College of Medicine he strengthened his knowledge and expertise on different imaging techniques such as FRET microscopy and intravital imaging. He studied spatiotemporal activation of RhoGTPases during invasive processes of tumor cells. In order to do that Dr Bravo-Cordero designed a series of imaging tools to study the regulation of GTPase activation in real time in living cells. From these studies, he defined molecular pathways as well as spatiotemporal kinetics of RhoGTPase signaling at invadopodia. His expertise ranges from microscopy to cell biology and mouse models. His studies, highly collaborative in nature, allow him to study tumor cell invasion in different tumor types, from different angles. These studies had uncovered novel functions and pathways in tumor cell invasion instrumental in understanding the early stages of metastasis. The work in his lab is focused on understanding how disseminated cancer cells construct niches to sustain dormancy at metastatic organs, and the role of ECM molecules and receptors in this process. The ultimate goal of his laboratory is to design therapeutic strategies to prevent metastatic recurrence by exploiting the mechanisms that cancer cells utilize to remain dormant at metastatic organs.

The event will be on Microsoft Teams.