We are delighted to be able to inform you of the MTWC for Fibrosing Lung Disease lecture series seminar talk taking place on Tuesday 27th February 2024.
The talk will be given by Professor Killian Hurley, RCSI University of Medicine and Health Sciences
Talk details as follows:-
Talk Title: Patient-derived induced pluripotent stem cells as tools to understand interstitial lung disease
Date: Tuesday 27th February 2024
Talk Time: 16:00 – 17:00 UK time
Location: Hybrid: Paul Wood Lecture Theatre, Guy Scadding Building, Ground Floor, Brompton Campus, Cale Street SW3 6LY & Online
Please note Registration is required to this event whether attending in person or online. For those attending in person there will also be a reception following the talk until 6pm
Bio:
Professor Hurley is a respiratory physician in Dublin and Associate Professor in the Royal College of Surgeons in Ireland. He performed his postdoctoral work in the Lab of Prof Darrell Kotton in Boston University before returning to Ireland in 2017. His clinical research is focused on understanding the genetic causes of pulmonary fibrosis. In the lab, his work seeks to better understand the causes of pulmonary fibrosis and find new treatments using patient-derived induced pluripotent stem cells to model disease. He has published on this topic in journals such as Cell Stem Cell, Nature Biotechnology and Stem Cell Reports. He is particularly interested in telomere related gene mutations as a cause of pulmonary fibrosis. In 2022, he was awarded a prestigious European Research Council Starting Grant to develop new gene therapies for patients with pulmonary fibrosis.
Talk Summary
Induced pluripotent stem cells (iPSC) are emerging tools to understand disease pathogenesis and find new treatments, especially for rare diseases where preclinical models are lacking. Recent advances in stem cell technology have made it possible to generate alveolar cells from iPSC by recapitulating key milestones in embryonic development. However, these iPSC-generated alveolar cells can be a heterogenous mix of non-target cells. In this seminar we will discuss how we develop pure cultures of alveolar cells and how iPSC from patients with rare inherited forms of ILD can be used to model disease and find new precision treatments for patients.
During the seminar, it will be important to:
1. Mute your microphone
2. Turn off the camera
Questions will be taken from those attending in person but if you would like to send a question through before the event please do send to admin.mtwc@imperial.ac.uk
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