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• Journal article
  Shah A, 2025,

  Patients’ perspectives on antimicrobial resistance in chronic respiratory disease: an AMR-Lung – European Lung Foundation global patient survey

  , ERJ Open Research, ISSN: 2312-0541
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• Journal article
  Howlett P, Szram J, Feary J, 2025,

  Occupational lung disease: What the general physician needs to know

  , Clinical Medicine, Journal of the Royal College of Physicians of London, Vol: 25, ISSN: 1470-2118

  Occupational exposures are a common and preventable cause of lung disease. About one in six cases of chronic obstructive pulmonary disease (COPD) and asthma worldwide are related to work. Early recognition of occupational lung disease improves outcomes. Doctors should ask about work history in patients with respiratory symptoms. This educational review article briefly outlines key clinical features, relevant to the general physician, of common occupational lung diseases seen in the UK. These conditions include work-related asthma, pneumoconioses, hypersensitivity pneumonitis and COPD. Referral to a specialist is recommended when an occupational cause is suspected. Most occupational lung diseases are preventable with adequate workplace safety measures and early medical attention.

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• Journal article
  Zhou Y, Sun M-L, Lin L, Ledesma-Amaro R, Wang K, Ji X-J, Huang Het al., 2025,

  Dynamic regulation combined with systematic metabolic engineering for high-level palmitoleic acid accumulation in oleaginous yeast.

  , Metab Eng, Vol: 89, Pages: 33-46

  Palmitoleic acid (POA, C16:1Δ9) is widely recognized for its preventive and therapeutic effects in various chronic and cardiovascular diseases, but the current production practices based on plant extraction are both economically and ecologically unsustainable. Although Yarrowia lipolytica is capable of producing POA, it only accumulates to a small percentage of total fatty acids. The present study aimed to enhance the accumulation of POA by employing a two-layer engineering strategy, encompassing the modulation of the fatty acid profile and the promotion of the accumulation of POA-rich lipids. The fatty acid profile was subject to modulation through the engineering of the fatty acid metabolism by expressing heterologous specific fatty acid desaturases CeFat5 and implementing dynamic regulation based on a copper-responsive promoter. Then, the mechanism underlying this improvement of POA production capacity was elucidated. Finally, the POA-rich lipid accumulation ability was enhanced through engineering of the lipid metabolism by overexpressing the heterologous POA-specific triacylglycerol forming acyltransferase, introducing the artificial designed non-carboxylative malonyl-CoA production pathway, and preventing lipid degradation. The resulting optimized yeast strain achieved an impressive POA accumulation accounting for 50.62% of total fatty acids, marking a 37.7-fold improvement over the initial strain. Moreover, a record POA titer of 25.6 g/L was achieved in the bioreactor. Overall, this study introduces a framework for establishing efficient yeast platforms for the accumulation of valuable fatty acids.

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• Journal article
  Bush A, Brochard LJ, Han MK, Chotirmall SH, Harhay MO, Martinez FJet al., 2025,

  Airtime for the Airway

  , American Journal of Respiratory and Critical Care Medicine, Vol: 211, Pages: 670-671, ISSN: 1073-449X
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• Report
  Coppens L, Bamezai S, Polizzi K, Frost G, Collins T, Carmichael R, Ledesma Amaro R, Corujo Simon Eet al., 2025,

  Microbial foods as a sustainable, healthy and resilient source of nutrients for the UK

  , Publisher: IMSE Institute
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• Journal article
  Dewachter I, Höglinger GU, Drucker DJ, Brown CE, Martin R, Chang AB, Chotirmall SH, Qi X, Shaw Pet al., 2025,

  A peek into the pipeline: Expert views on emerging therapies

  , Cell Reports Medicine, Vol: 6
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• Journal article
  Öztürk HB, Verdross P, Bismarck A, 2025,

  Black liquor derived lignin adsorbents for removal of organic pollutants from water

  , Reactive and Functional Polymers, Vol: 209, ISSN: 1381-5148

  We present the preparation of lignin particles from raw black liquor and their chemical modification, so that they can be used as efficient adsorbents to remove organic pollutants from water. For the production of adsorbent powders, pristine black liquor (as obtained from a pulping mill) was emulsified with epichlorohydrin and Span 80 and cured at elevated temperatures. Phospinic esters and organic sulphates were synthetically introduced to the lignin-backbone to modify the adsorbents. The adsorption of organic model compounds, Paraquat, p-nitrophenol, and malachite green were studied. Kinetic and thermodynamic data of the adsorption processes was obtained experimentally and by fitting mathematical models (Langmuir and Freundlich isotherms). Adsorbents showed adsorption capacities of Qe = 62 mg/g for Paraquat, Qe = 199 mg/g for p-nitrophenol, and Qe = 1200 mg/g for malachite green in batch-adsorption experiments. These values are among the highest for any of the model compounds presented in literature. Adsorption occurred reasonably fast for all compounds, reaching plateau-adsorption within minutes to hours.

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• Journal article
  Hummer S, Barkan-Öztürk H, Bismarck A, Woodward RTet al., 2025,

  Ready, steady, flow: Pd-loaded hypercrosslinked microreactors for the flow synthesis of paracetamol

  , Applied Materials Today, Vol: 43, ISSN: 2352-9407

  We describe the implementation of monolithic polymerised high internal phase emulsions (polyHIPEs) as catalyst supports for the continuous flow synthesis of paracetamol. PolyHIPEs are formed by polymerisation of particle and surfactant-stabilised water-in-oil HIPEs comprising of a divinylbenzene and divinylbenzene/4-vinylbenzyl chloride monomer continuous phase. The polyHIPEs were post-functionalised by hypercrosslinking using the Scholl coupling reaction to yield polymers decorated with organophosphorus moieties and surface areas of up to 500 m²/g. The phosphorus moieties act as catalyst anchor sites for the subsequent loading of Pd via a Pd−O=P ligand bridge. The Pd-loaded polyHIPEs are used as catalysts for the reduction of 4-nitrophenol to 4-aminophenol, achieving turnover numbers of ∼2,000. The Pd-loaded polyHIPEs and non-functionalised divinylbenzene-based polyHIPEs are fabricated into flow-cells and used en route to Plant-on-a-Bench as microreactor/mixer for the continuous flow synthesis of paracetamol in yields of 66%.

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• Journal article
  Carter C, Shah A, 2025,

  The Fungal Frontier: Understanding the Impact of Aspergillus in Bronchiectasis

  , Chest, Vol: 167, Pages: 914-916, ISSN: 0012-3692
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• Journal article
  Xue Y, Verdross P, Liang W, Woodward RT, Bismarck Aet al., 2025,

  Breaking the ice: Applications of photothermal superhydrophobic materials for efficient deicing strategies.

  , Adv Colloid Interface Sci, Vol: 341

  The accumulation of ice on the surfaces of devices has long been a significant concern for human life and production. The icing of aircraft surfaces can alter the aerodynamic shape of the aircraft, reducing its controllability and decrease the flight range. Ice buildup on wind turbine blades significantly reduces power generation efficiency. Preventing ice accumulation has thus become a focal point of research. Photothermal superhydrophobic materials are characterized by efficient photothermal energy conversion upon irradiation, thus showing promise for applications in the energy-, civil- or aerospace-engineering sectors. Photothermal superhydrophobic materials are promise to be a safe, reliable and cost-effective anti-icing/deicing strategies. In this review, the design concepts, preparation methods, performance characteristics, and application areas of different types of photothermal superhydrophobic materials are discussed. After elucidating anti-icing mechanisms, the superhydrophobic photothermal material state-of-the-art is reviewed. The problems encountered in the practical application of photothermal superhydrophobic materials and challenges to be addressed in the future are also analyzed and discussed.

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