Translational and Clinical Research
Below is an outline of early clinical and preclinical research activities focussed on therapeutics in the field of haematology, involving avademics from the Centre for Haematology.
Haemato-Oncology
- Multiple Myeloma: First in man clinical development of GADDβ45 inhibitor.
- Pre-clinical development of GCN2 and PBX1 inhibitors
- HTLV-1 adult T cell lymphoma: Clinical development of anti-CCR4 Ab for treatment of pre-malignant ATL
- Clinical and pre-clinical development of iNKT cell-based immunotherapy
- Stem cell transplantation and cellular immunotherapy (point of care CAR-T immunotherapy).
Red cell haematology and Immunohaematology
- Haemoglobinopathies and Thalassaemias: Gene therapy including gene editing
- Hereditary haemolytic anaemias: Novel allosteric glycolytic enzyme modulators
- Immune thrombocytopenia: Novel immunomodulating small molecules.
Thrombosis and Haemostasis
- Discovery and pre-clinical developments of raft of mAbs as novel anti-coagulations