In this section
@article{Hamilton:2019:10.12688/f1000research.18557.1,
author = {Hamilton, C and Anand, PK},
doi = {10.12688/f1000research.18557.1},
journal = {F1000Research},
title = {Right place, right time: Localisation and assembly of the NLRP3 inflammasome},
url = {http://dx.doi.org/10.12688/f1000research.18557.1},
volume = {8},
year = {2019}
}
TY - JOUR
AB - The NLRP3 inflammasome is a multimeric protein complex that cleavescaspase-1 and the pro-inflammatory cytokines interleukin 1 beta (IL-1β)and IL-18. Dysregulated NLRP3 inflammasome signalling is linked toseveral chronic inflammatory and autoimmune conditions; thus,understanding the activation mechanisms of the NLRP3 inflammasome isessential. Studies over the past few years have implicated vital roles fordistinct intracellular organelles in both the localisation and assembly of the NLRP3 inflammasome. However, conflicting reports exist. Prior to itsactivation, NLRP3 has been shown to be resident in the endoplasmicreticulum (ER) and cytosol, although, upon activation, the NLRP3inflammasome has been shown to assemble in the cytosol, mitochondria,and mitochondria-associated ER membranes by different reports. Finally,very recent work has suggested that NLRP3 may be localised on oradjacent to the Golgi apparatus and that release of mediators from thisorganelle may contribute to inflammasome assembly. Therefore, NLRP3may be strategically placed on or in close proximity to these subcellularcompartments to both sense danger signals originating from theseorganelles and use the compartment as a scaffold to assemble thecomplex. Understanding where and when NLRP3 inflammasome assembly occurs may help identify potential targets for treatment of NLRP3-related disorders.
AU - Hamilton,C
AU - Anand,PK
DO - 10.12688/f1000research.18557.1
PY - 2019///
SN - 2046-1402
TI - Right place, right time: Localisation and assembly of the NLRP3 inflammasome
T2 - F1000Research
UR - http://dx.doi.org/10.12688/f1000research.18557.1
VL - 8
ER -