In this section
@article{Dharmage:2019:10.3389/fped.2019.00246,
author = {Dharmage, SC and Perret, JL and Custovic, A},
doi = {10.3389/fped.2019.00246},
journal = {Frontiers in Pediatrics},
title = {Epidemiology of asthma in children and adults},
url = {http://dx.doi.org/10.3389/fped.2019.00246},
volume = {7},
year = {2019}
}
TY - JOUR
AB - Asthma is a globally significant non-communicable disease with major public health consequences for both children and adults, including high morbidity, and mortality in severe cases. We have summarized the evidence on asthma trends, environmental determinants, and long-term impacts while comparing these epidemiological features across childhood asthma and adult asthma. While asthma incidence and prevalence are higher in children, morbidity, and mortality are higher in adults. Childhood asthma is more common in boys while adult asthma is more common in women, and the reversal of this sex difference in prevalence occurs around puberty suggesting sex hormones may play a role in the etiology of asthma. The global epidemic of asthma that has been observed in both children and adults is still continuing, especially in low to middle income countries, although it has subsided in some developed countries. As a heterogeneous disease, distinct asthma phenotypes, and endotypes need to be adequately characterized to develop more accurate and meaningful definitions for use in research and clinical settings. This may be facilitated by new clustering techniques such as latent class analysis, and computational phenotyping methods are being developed to retrieve information from electronic health records using natural language processing (NLP) algorithms to assist in the early diagnosis of asthma. While some important environmental determinants that trigger asthma are well-established, more work is needed to define the role of environmental exposures in the development of asthma in both children and adults. There is increasing evidence that investigation into possible gene-by-environment and environment-by-environment interactions may help to better uncover the determinants of asthma. Therefore, there is an urgent need to further investigate the interrelationship between environmental and genetic determinants to identify high risk groups and key modifiable exposures. For children, as
AU - Dharmage,SC
AU - Perret,JL
AU - Custovic,A
DO - 10.3389/fped.2019.00246
PY - 2019///
SN - 2296-2360
TI - Epidemiology of asthma in children and adults
T2 - Frontiers in Pediatrics
UR - http://dx.doi.org/10.3389/fped.2019.00246
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000472021200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL - 7
ER -