Citation

BibTex format

@article{Wren:2001:10.1210/jcem.86.12.8111,
author = {Wren, AM and Seal, LJ and Cohen, MA and Brynes, AE and Frost, GS and Murphy, KG and Dhillo, WS and Ghatei, MA and Bloom, SR},
doi = {10.1210/jcem.86.12.8111},
journal = {The Journal of Clinical Endocrinology & Metabolism},
pages = {5992--5992},
title = {Ghrelin Enhances Appetite and Increases Food Intake in Humans},
url = {http://dx.doi.org/10.1210/jcem.86.12.8111},
volume = {86},
year = {2001}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:p>Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly in the stomach and found in the circulation of healthy humans. Ghrelin has been shown to promote increased food intake, weight gain and adiposity in rodents. The effect of ghrelin on appetite and food intake in man has not been determined. We investigated the effects of intravenous ghrelin (5.0 pmol/kg/min) or saline infusion on appetite and food intake in a randomised double-blind cross-over study in nine healthy volunteers. There was a clear-cut increase in energy consumed by every individual from a free-choice buffet (mean increase 28 ± 3.9%, p&lt;0.001) during ghrelin compared with saline infusion. Visual analogue scores for appetite were greater during ghrelin compared to saline infusion. Ghrelin had no effect on gastric emptying as assessed by the paracetamol absorption test. Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man. Endogenous ghrelin is a potentially important new regulator of the complex systems controlling food intake and body weight.</jats:p>
AU  - Wren,AM
AU  - Seal,LJ
AU  - Cohen,MA
AU  - Brynes,AE
AU  - Frost,GS
AU  - Murphy,KG
AU  - Dhillo,WS
AU  - Ghatei,MA
AU  - Bloom,SR
DO  - 10.1210/jcem.86.12.8111
EP  - 5992
PY  - 2001///
SN  - 0021-972X
SP  - 5992
TI  - Ghrelin Enhances Appetite and Increases Food Intake in Humans
T2  - The Journal of Clinical Endocrinology & Metabolism
UR  - http://dx.doi.org/10.1210/jcem.86.12.8111
UR  - https://doi.org/10.1210/jcem.86.12.8111
VL  - 86
ER  -
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