Citation

BibTex format

@article{Holguin:2020:10.1183/13993003.00588-2019,
author = {Holguin, F and Cardet, JC and Chung, KF and Diver, S and Ferreira, DS and Fitzpatrick, A and Gaga, M and Kellermeyer, L and Khurana, S and Knight, S and McDonald, VM and Morgan, RL and Ortega, VE and Rigau, D and Subbarao, P and Tonia, T and Adcock, IM and Bleecker, ER and Brightling, C and Boulet, L-P and Cabana, M and Castro, M and Chanez, P and Custovic, A and Djukanovic, R and Frey, U and Frankemolle, B and Gibson, P and Hamerlijnck, D and Jarjour, N and Konno, S and Shen, H and Vitary, C and Bush, A},
doi = {10.1183/13993003.00588-2019},
journal = {European Respiratory Journal},
title = {Management of severe asthma: a European Respiratory Society/American Thoracic Society Guideline},
url = {http://dx.doi.org/10.1183/13993003.00588-2019},
volume = {55},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This document provides clinical recommendations for the management of severe asthma. Comprehensive evidence syntheses, including meta-analyses, were performed to summarise all available evidence relevant to the Task Force's questions. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach and the results were summarised in evidence profiles. The evidence syntheses were discussed and recommendations formulated by a multidisciplinary Task Force of asthma experts, who made specific recommendations on 6 specific questions. After considering the balance of desirable and undesirable consequences, quality of evidence, feasibility, and acceptability of various interventions, the Task Force made the following recommendations: 1) Suggest using anti-IL5 and anti IL-5Rα for severe uncontrolled adult eosinophilic asthma phenotypes; 2) suggest using blood eosinophil cut-point of ≥150/μL to guide anti-IL5 initiation in adult patients with severe asthma; and 3) Suggest considering specific eosinophil (≥260/μL) and FeNO (≥19.5ppb) cutoffs to identify adolescents or adults with the greatest likelihood or response to anti-IgE therapy; 4) Suggest using inhaled tiotropium for adolescents and adults with severe uncontrolled asthma despite GINA step 4-5 or NAEPP step 5 therapies; 5) Suggest a trial of chronic macrolide therapy to reduce asthma exacerbations in persistently symptomatic or uncontrolled patients on GINA step 5 or NAEPP step 5 therapies, irrespective of asthma phenotype; 6) Suggest using anti-IL4/13 for adult patients with severe eosinophilic asthma, and for those with severe corticosteroid-dependent asthma regardless of blood eosinophil levels. These recommendations should be reconsidered as new evidence becomes available.
AU  - Holguin,F
AU  - Cardet,JC
AU  - Chung,KF
AU  - Diver,S
AU  - Ferreira,DS
AU  - Fitzpatrick,A
AU  - Gaga,M
AU  - Kellermeyer,L
AU  - Khurana,S
AU  - Knight,S
AU  - McDonald,VM
AU  - Morgan,RL
AU  - Ortega,VE
AU  - Rigau,D
AU  - Subbarao,P
AU  - Tonia,T
AU  - Adcock,IM
AU  - Bleecker,ER
AU  - Brightling,C
AU  - Boulet,L-P
AU  - Cabana,M
AU  - Castro,M
AU  - Chanez,P
AU  - Custovic,A
AU  - Djukanovic,R
AU  - Frey,U
AU  - Frankemolle,B
AU  - Gibson,P
AU  - Hamerlijnck,D
AU  - Jarjour,N
AU  - Konno,S
AU  - Shen,H
AU  - Vitary,C
AU  - Bush,A
DO  - 10.1183/13993003.00588-2019
PY  - 2020///
SN  - 0903-1936
TI  - Management of severe asthma: a European Respiratory Society/American Thoracic Society Guideline
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.00588-2019
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31558662
VL  - 55
ER  -
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