BibTex format
@article{Stirrup:2019,
author = {Stirrup, OT and Sabin, CA and Phillips, AN and Williams, I and Churchill, D and Tostevin, A and Hill, T and Dunn, DT and Asboe, D and Pozniak, A and Cane, P and Chadwick, D and Clark, D and Collins, S and Delpech, V and Douthwaite, S and Dunn, D and Fearnhill, E and Porter, K and Stirrup, O and Fraser, C and Geretti, AM and Gunson, R and Hale, A and Hue, S and Lazarus, L and Leigh-Brown, A and Mbisa, T and Mackie, N and Orkin, C and Nastouli, E and Pillay, D and Phillips, A and Sabin, C and Smit, E and Templeton, K and Tilston, P and Volz, E and Zhang, H and Fairbrother, K and Dawkins, J and O'Shea, S and Mullen, J and Cox, A and Tandy, R and Fawcett, T and Hopkins, M and Booth, C and Garcia-Diaz, A and Renwick, L and Schmid, ML and Payne, B and Hubb, J and Dustan, S and Kirk, S and Bradley-Stewart, A and Ainsworth, J and Allan, S and Anderson, J and Babiker, A and Gazzard, B and Gilson, R and Compels, M and Hay, P and Johnson, M and Jose, S and Kegg, S and Leen, C and Martin, F and Mi},
journal = {Journal of virus eradication},
pages = {204--211},
title = {Associations between baseline characteristics, CD4 cell count response and virological failure on first-line efavirenz},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000494967100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202},
volume = {5},
year = {2019}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - ObjectivesThe aim of this study was to investigate associations between baseline characteristics and CD4 cell count response on first-line antiretroviral therapy and risk of virological failure (VF) with or without drug resistance.MethodsWe conducted an analysis of UK Collaborative HIV Cohort data linked to the UK HIV Drug Resistance Database. Inclusion criteria were viral sequence showing no resistance prior to initiation of first-line efavirenz + tenofovir disoproxil fumarate + emtricitabine and virological suppression within 6 months. Outcomes of VF (≥200 copies/mL) with or without drug resistance were assessed using a competing risks approach fitted jointly with a model for CD4 cell count recovery. Hazard ratios for each VF outcome were estimated for baseline CD4 cell count and viral load and characteristics of CD4 cell count response using latent variables on a standard normal scale.ResultsA total of 3640 people were included with 338 VF events; corresponding viral sequences were available in 134 with ≥1 resistance mutation in 36. VF with resistance was associated with lower baseline CD4 (0.30, 0.09–0.62), lower CD4 recovery (0.04, 0.00–0.17) and higher CD4 variability (4.40, 1.22–12.68). A different pattern of associations was observed for VF without resistance, but the strength of these results was less consistent across sensitivity analyses. Cumulative incidence of VF with resistance was estimated to be <2% at 3 years for baseline CD4 ≥350 cells/μL.ConclusionLower baseline CD4 cell count and suboptimal CD4 recovery are associated with VF with drug resistance. People with low CD4 cell count before ART or with suboptimal CD4 recovery on treatment should be a priority for regimens with high genetic barrier to resistance.
AU - Stirrup,OT
AU - Sabin,CA
AU - Phillips,AN
AU - Williams,I
AU - Churchill,D
AU - Tostevin,A
AU - Hill,T
AU - Dunn,DT
AU - Asboe,D
AU - Pozniak,A
AU - Cane,P
AU - Chadwick,D
AU - Clark,D
AU - Collins,S
AU - Delpech,V
AU - Douthwaite,S
AU - Dunn,D
AU - Fearnhill,E
AU - Porter,K
AU - Stirrup,O
AU - Fraser,C
AU - Geretti,AM
AU - Gunson,R
AU - Hale,A
AU - Hue,S
AU - Lazarus,L
AU - Leigh-Brown,A
AU - Mbisa,T
AU - Mackie,N
AU - Orkin,C
AU - Nastouli,E
AU - Pillay,D
AU - Phillips,A
AU - Sabin,C
AU - Smit,E
AU - Templeton,K
AU - Tilston,P
AU - Volz,E
AU - Zhang,H
AU - Fairbrother,K
AU - Dawkins,J
AU - O'Shea,S
AU - Mullen,J
AU - Cox,A
AU - Tandy,R
AU - Fawcett,T
AU - Hopkins,M
AU - Booth,C
AU - Garcia-Diaz,A
AU - Renwick,L
AU - Schmid,ML
AU - Payne,B
AU - Hubb,J
AU - Dustan,S
AU - Kirk,S
AU - Bradley-Stewart,A
AU - Ainsworth,J
AU - Allan,S
AU - Anderson,J
AU - Babiker,A
AU - Gazzard,B
AU - Gilson,R
AU - Compels,M
AU - Hay,P
AU - Johnson,M
AU - Jose,S
AU - Kegg,S
AU - Leen,C
AU - Martin,F
AU - Mital,D
AU - Nelson,M
AU - Palfreeman,A
AU - Post,F
AU - Pritchard,J
AU - Schwenk,A
AU - Tariq,A
AU - Trevelion,R
AU - Ustianowski,A
AU - Walsh,J
AU - Thornton,A
AU - Huntington,S
AU - Glabay,A
AU - Shidfar,S
AU - Lynch,J
AU - Hand,J
AU - de,Souza C
AU - Perry,N
AU - Tilbury,S
AU - Youssef,E
AU - Mabika,T
AU - Mandalia,S
AU - Munshi,S
AU - Adefisan,A
AU - Taylor,C
AU - Gleisner,Z
AU - Ibrahim,F
AU - Campbell,L
AU - Baillie,K
AU - Brima,N
AU - Miller,S
AU - Wood,C
AU - Youle,M
AU - Lampe,F
AU - Smith,C
AU - Tsintas,R
AU - Chaloner,C
AU - Hutchinson,S
AU - Mackie,N
AU - Winston,A
AU - Weber,J
AU - Ramzan,F
AU - Carder,M
AU - Wilson,A
AU - Morris,S
AU - Gompels,M
AU - Allan,S
AU - Lewszuk,A
AU - Faleye,A
AU - Ogunbiyi,V
AU - Mitchell,S
AU - Kemble,C
AU - Russell-Sharpe,S
AU - Gravely,J
AU - Harte,A
AU - Spencer,H
AU - Jones,R
AU - Cumming,S
AU - Atkinson,C
AU - Edgell,V
AU - Allen,J
AU - Murphy,C
AU - Gunder,I
EP - 211
PY - 2019///
SN - 2055-6640
SP - 204
TI - Associations between baseline characteristics, CD4 cell count response and virological failure on first-line efavirenz
T2 - Journal of virus eradication
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000494967100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844404/
VL - 5
ER -