Citation

BibTex format

@misc{Parks:2019:10.1101/559161,
author = {Parks, T and Elliott, K and Lamagni, T and Auckland, K and Mentzer, A and Guy, R and Cartledge, D and Strakova, L and OConnor, D and Pollard, A and Neville, M and Mahajan, A and Ashrafian, H and Chapman, S and Hill, A and Sriskandan, S and Knight, J},
doi = {10.1101/559161},
title = {Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leukocyte antigen locus},
type = {Other},
url = {http://dx.doi.org/10.1101/559161},
year = {2019}
}
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TY  - GEN
AB  - Invasive group A streptococcal (GAS) disease is uncommon but carries a high case-fatality rate relative to other infectious diseases. Given the ubiquity of mild GAS infections, it remains unclear why healthy individuals will occasionally develop life-threatening infections, raising the possibility of host genetic predisposition. Here, we present the results of a case-control study including 43 invasive GAS cases and 1,540 controls. Using HLA imputation and linear mixed-models, we find each copy of the HLA-DQA1 01:03 allele associates with a two-fold increased risk of disease (odds ratio 2.3, 95% confidence interval 1.3-4.4, P =0.009), an association which persists with classical HLA typing of a subset of cases and analysis with an alternative large control dataset with validated HLA data. Moreover, we propose the association is driven by the allele itself rather than the background haplotype. Overall this finding provides impetus for further investigation of the immunogenetic basis of this devastating bacterial disease.
AU  - Parks,T
AU  - Elliott,K
AU  - Lamagni,T
AU  - Auckland,K
AU  - Mentzer,A
AU  - Guy,R
AU  - Cartledge,D
AU  - Strakova,L
AU  - OConnor,D
AU  - Pollard,A
AU  - Neville,M
AU  - Mahajan,A
AU  - Ashrafian,H
AU  - Chapman,S
AU  - Hill,A
AU  - Sriskandan,S
AU  - Knight,J
DO  - 10.1101/559161
PY  - 2019///
TI  - Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leukocyte antigen locus
UR  - http://dx.doi.org/10.1101/559161
ER  -
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