BibTex format
@article{Lo:2022:10.1002/eji.202149228,
author = {Lo, JW and de, Mucha MV and Henderson, S and Roberts, LB and Constable, LE and Garrido-Mesa, N and Hertweck, A and Stolarczyk, E and Houlder, EL and Jackson, I and MacDonald, AS and Powell, N and Neves, JF and Howard, JK and Jenner, RG and Lord, GM},
doi = {10.1002/eji.202149228},
journal = {European Journal of Immunology},
pages = {566--581},
title = {A population of naive-like CD4(+) T cells stably polarized to the T(H)1 lineage},
url = {http://dx.doi.org/10.1002/eji.202149228},
volume = {52},
year = {2022}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - T-bet is the lineage-specifying transcription factor for CD4+ TH1 cells. T-bet has also been found in other CD4+ T cell subsets, including TH17 cells and Treg, where it modulates their functional characteristics. However, we lack information on when and where T-bet is expressed during T cell differentiation and how this impacts T cell differentiation and function. To address this, we traced the ontogeny of T-bet-expressing cells using a fluorescent fate-mapping mouse line. We demonstrate that T-bet is expressed in a subset of CD4+ T cells that have naïve cell surface markers and transcriptional profile and that this novel cell population is phenotypically and functionally distinct from previously described populations of naïve and memory CD4+ T cells. Naïve-like T-bet-experienced cells are polarized to the TH1 lineage, predisposed to produce IFN-γ upon cell activation, and resist repolarization to other lineages in vitro and in vivo. These results demonstrate that lineage-specifying factors can polarize T cells in the absence of canonical markers of T cell activation and that this has an impact on the subsequent T-helper response.
AU - Lo,JW
AU - de,Mucha MV
AU - Henderson,S
AU - Roberts,LB
AU - Constable,LE
AU - Garrido-Mesa,N
AU - Hertweck,A
AU - Stolarczyk,E
AU - Houlder,EL
AU - Jackson,I
AU - MacDonald,AS
AU - Powell,N
AU - Neves,JF
AU - Howard,JK
AU - Jenner,RG
AU - Lord,GM
DO - 10.1002/eji.202149228
EP - 581
PY - 2022///
SN - 0014-2980
SP - 566
TI - A population of naive-like CD4(+) T cells stably polarized to the T(H)1 lineage
T2 - European Journal of Immunology
UR - http://dx.doi.org/10.1002/eji.202149228
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000754327900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR - https://onlinelibrary.wiley.com/doi/10.1002/eji.202149228
VL - 52
ER -