BibTex format
@unpublished{Barbosa:2020:10.1101/2020.04.12.038414,
author = {Barbosa, RR and Xu, AQ and DAndrea, D and Copley, F and Patel, H and Chakravarty, P and Clear, A and Calaminici, M and Janz, M and Zhang, B and Schmidt-Supprian, M and Wang, J and Gribben, JG and Tooze, R and Fitzgibbon, J and Franzoso, G and Rajewsky, K and Calado, DP},
doi = {10.1101/2020.04.12.038414},
publisher = {Cold Spring Harbor Laboratory},
title = {Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability},
url = {http://dx.doi.org/10.1101/2020.04.12.038414},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - UNPB
AB - NF-κB and MYC are found co-deregulated in human B and plasma-cell cancers. In physiology, NF-κB is necessary for terminal B-to-plasma cell differentiation, whereas MYC repression is required. It is thus unclear if NF-κB/MYC co-deregulation is developmentally compatible in carcinogenesis and/or impacts cancer cell differentiation state, possibly uncovering unique sensitivities. Using a mouse system to trace cell lineage and oncogene activation we found that NF-κB/MYC co-deregulation originated cancers with a plasmablast-like phenotype, alike human plasmablastic-lymphoma and was linked to t(8;14)[MYC-IGH] multiple myeloma. Notably, in contrast to NF-κB or MYC activation alone, co-deregulation rendered cells addicted to IL6 for survival and phenotypic stability. We propose that conflicting oncogene-driven differentiation pressures can be accommodated at a cost in poorly-differentiated cancers.
AU - Barbosa,RR
AU - Xu,AQ
AU - DAndrea,D
AU - Copley,F
AU - Patel,H
AU - Chakravarty,P
AU - Clear,A
AU - Calaminici,M
AU - Janz,M
AU - Zhang,B
AU - Schmidt-Supprian,M
AU - Wang,J
AU - Gribben,JG
AU - Tooze,R
AU - Fitzgibbon,J
AU - Franzoso,G
AU - Rajewsky,K
AU - Calado,DP
DO - 10.1101/2020.04.12.038414
PB - Cold Spring Harbor Laboratory
PY - 2020///
TI - Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability
UR - http://dx.doi.org/10.1101/2020.04.12.038414
UR - https://www.biorxiv.org/content/10.1101/2020.04.12.038414v1
ER -