BibTex format
@article{Milighetti:2023:10.1016/j.isci.2023.106937,
author = {Milighetti, M and Peng, Y and Tan, C and Mark, M and Nageswaran, G and Byrne, S and Ronel, T and Peacock, T and Mayer, A and Chandran, A and Rosenheim, J and Whelan, M and Yao, X and Liu, G and Felce, SL and Dong, T and Mentzer, AJ and Knight, JC and Balloux, F and Greenstein, E and Reich-Zeliger, S and Pade, C and Gibbons, JM and Semper, A and Brooks, T and Otter, A and Altmann, DM and Boyton, RJ and Maini, MK and McKnight, A and Manisty, C and Treibel, TA and Moon, JC and COVIDsortium, Investigators and Noursadeghi, M and Chain, B},
doi = {10.1016/j.isci.2023.106937},
journal = {iScience},
pages = {1--20},
title = {Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection},
url = {http://dx.doi.org/10.1016/j.isci.2023.106937},
volume = {26},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of individual T cell clones immediately. In SARS-COV-2 PCR+ individuals, a wave of TCRs strongly but transiently expand, frequently peaking the same week as the first positive PCR test. These expanding TCR CDR3s were enriched for sequences functionally annotated as SARS-COV-2 specific. Epitopes recognized by the expanding TCRs were highly conserved between SARS-COV-2 strains but not with circulating human coronaviruses. Many expanding CDR3s were present at high frequency in pre-pandemic repertoires. Early response TCRs specific for lymphocytic choriomeningitis virus epitopes were also found at high frequency in the preinfection naive repertoire. High-frequency naive precursors may allow the T cell response to respond rapidly during the crucial early phases of acute viral infection.
AU - Milighetti,M
AU - Peng,Y
AU - Tan,C
AU - Mark,M
AU - Nageswaran,G
AU - Byrne,S
AU - Ronel,T
AU - Peacock,T
AU - Mayer,A
AU - Chandran,A
AU - Rosenheim,J
AU - Whelan,M
AU - Yao,X
AU - Liu,G
AU - Felce,SL
AU - Dong,T
AU - Mentzer,AJ
AU - Knight,JC
AU - Balloux,F
AU - Greenstein,E
AU - Reich-Zeliger,S
AU - Pade,C
AU - Gibbons,JM
AU - Semper,A
AU - Brooks,T
AU - Otter,A
AU - Altmann,DM
AU - Boyton,RJ
AU - Maini,MK
AU - McKnight,A
AU - Manisty,C
AU - Treibel,TA
AU - Moon,JC
AU - COVIDsortium,Investigators
AU - Noursadeghi,M
AU - Chain,B
DO - 10.1016/j.isci.2023.106937
EP - 20
PY - 2023///
SN - 2589-0042
SP - 1
TI - Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection
T2 - iScience
UR - http://dx.doi.org/10.1016/j.isci.2023.106937
UR - https://www.ncbi.nlm.nih.gov/pubmed/37275518
UR - https://www.sciencedirect.com/science/article/pii/S2589004223010143
VL - 26
ER -