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BibTex format

@article{Amaral:2024:10.1038/s41564-023-01523-7,
author = {Amaral, EP and Namasivayam, S and Queiroz, ATL and Fukutani, E and Hilligan, KL and Aberman, K and Fisher, L and Bomfim, CCB and Kauffman, K and Buchanan, J and Santuo, L and Gazzinelli-Guimaraes, PH and Costa, DL and Teixeira, MA and Barreto-Duarte, B and Rocha, CG and Santana, MF and Cordeiro-Santos, M and Barber, DL and Wilkinson, RJ and Kramnik, I and Igarashi, K and Scriba, T and Mayer-Barber, KD and Andrade, BB and Sher, A},
doi = {10.1038/s41564-023-01523-7},
journal = {Nature Microbiology},
pages = {120--135},
title = {BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility},
url = {http://dx.doi.org/10.1038/s41564-023-01523-7},
volume = {9},
year = {2024}
}
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TY  - JOUR
AB  - Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, a transcription factor that represses multiple antioxidant genes, regulates host resistance to Mtb. We found that BACH1 expression is associated clinically with active pulmonary tuberculosis. Bach1 deletion in Mtb-infected mice increased glutathione levels and Gpx4 expression that inhibit lipid peroxidation. Bach1-/- macrophages exhibited increased resistance to Mtb-induced cell death, while Mtb-infected Bach1-deficient mice displayed reduced bacterial loads, pulmonary necrosis and lipid peroxidation concurrent with increased survival. Single-cell RNA-seq analysis of lungs from Mtb-infected Bach1-/- mice revealed an enrichment of genes associated with ferroptosis suppression. Bach1 depletion in Mtb-infected B6.Sst1S mice that display human-like necrotic lung pathology also markedly reduced necrosis and increased host resistance. These findings identify Bach1 as a key regulator of cellular and tissue necrosis and host resistance in Mtb infection.
AU  - Amaral,EP
AU  - Namasivayam,S
AU  - Queiroz,ATL
AU  - Fukutani,E
AU  - Hilligan,KL
AU  - Aberman,K
AU  - Fisher,L
AU  - Bomfim,CCB
AU  - Kauffman,K
AU  - Buchanan,J
AU  - Santuo,L
AU  - Gazzinelli-Guimaraes,PH
AU  - Costa,DL
AU  - Teixeira,MA
AU  - Barreto-Duarte,B
AU  - Rocha,CG
AU  - Santana,MF
AU  - Cordeiro-Santos,M
AU  - Barber,DL
AU  - Wilkinson,RJ
AU  - Kramnik,I
AU  - Igarashi,K
AU  - Scriba,T
AU  - Mayer-Barber,KD
AU  - Andrade,BB
AU  - Sher,A
DO  - 10.1038/s41564-023-01523-7
EP  - 135
PY  - 2024///
SN  - 2058-5276
SP  - 120
TI  - BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility
T2  - Nature Microbiology
UR  - http://dx.doi.org/10.1038/s41564-023-01523-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38066332
UR  - https://www.nature.com/articles/s41564-023-01523-7
VL  - 9
ER  -
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