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BibTex format

@article{Jia:2024:10.1016/j.cell.2024.07.026,
author = {Jia, X and Crawford, JC and Gebregzabher, D and Monson, EA and Mettelman, RC and Wan, Y and Ren, Y and Chou, J and Novak, T and McQuilten, HA and Clarke, M and Bachem, A and Foo, IJ and Fritzlar, S and Carrera, Montoya J and Trenerry, AM and Nie, S and Leeming, MG and Nguyen, THO and Kedzierski, L and Littler, DR and Kueh, A and Cardamone, T and Wong, CY and Hensen, L and Cabug, A and Laguna, JG and Agrawal, M and Flerlage, T and Boyd, DF and Van, de Velde L-A and Habel, JR and Loh, L and Koay, H-F and van, de Sandt CE and Konstantinov, IE and Berzins, SP and Flanagan, KL and Wakim, LM and Herold, MJ and Green, AM and Smallwood, HS and Rossjohn, J and Thwaites, RS and Chiu, C and Scott, NE and Mackenzie, JM and Bedoui, S and Reading, PC and Londrigan, SL and Helbig, KJ and Randolph, AG and Thomas, PG and Xu, J and Wang, Z and Chua, BY and Kedzierska, K},
doi = {10.1016/j.cell.2024.07.026},
journal = {Cell},
pages = {4586--4604},
title = {High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases},
url = {http://dx.doi.org/10.1016/j.cell.2024.07.026},
volume = {187},
year = {2024}
}
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TY  - JOUR
AB  - Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning fatal disease. Transcriptomics strongly linked oleoyl-acyl-carrier-protein (ACP) hydrolase (OLAH), an enzyme mediating fatty acid production, with fatal A(H7N9) early after hospital admission, persisting until death. Recovered patients had low OLAH expression throughout hospitalization. High OLAH levels were also detected in patients hospitalized with life-threatening seasonal influenza, COVID-19, respiratory syncytial virus (RSV), and multisystem inflammatory syndrome in children (MIS-C) but not during mild disease. In olah-/- mice, lethal influenza infection led to survival and mild disease as well as reduced lung viral loads, tissue damage, infection-driven pulmonary cell infiltration, and inflammation. This was underpinned by differential lipid droplet dynamics as well as reduced viral replication and virus-induced inflammation in macrophages. Supplementation of oleic acid, the main product of OLAH, increased influenza replication in macrophages and their inflammatory potential. Our findings define how the expression of OLAH drives life-threatening viral disease.
AU  - Jia,X
AU  - Crawford,JC
AU  - Gebregzabher,D
AU  - Monson,EA
AU  - Mettelman,RC
AU  - Wan,Y
AU  - Ren,Y
AU  - Chou,J
AU  - Novak,T
AU  - McQuilten,HA
AU  - Clarke,M
AU  - Bachem,A
AU  - Foo,IJ
AU  - Fritzlar,S
AU  - Carrera,Montoya J
AU  - Trenerry,AM
AU  - Nie,S
AU  - Leeming,MG
AU  - Nguyen,THO
AU  - Kedzierski,L
AU  - Littler,DR
AU  - Kueh,A
AU  - Cardamone,T
AU  - Wong,CY
AU  - Hensen,L
AU  - Cabug,A
AU  - Laguna,JG
AU  - Agrawal,M
AU  - Flerlage,T
AU  - Boyd,DF
AU  - Van,de Velde L-A
AU  - Habel,JR
AU  - Loh,L
AU  - Koay,H-F
AU  - van,de Sandt CE
AU  - Konstantinov,IE
AU  - Berzins,SP
AU  - Flanagan,KL
AU  - Wakim,LM
AU  - Herold,MJ
AU  - Green,AM
AU  - Smallwood,HS
AU  - Rossjohn,J
AU  - Thwaites,RS
AU  - Chiu,C
AU  - Scott,NE
AU  - Mackenzie,JM
AU  - Bedoui,S
AU  - Reading,PC
AU  - Londrigan,SL
AU  - Helbig,KJ
AU  - Randolph,AG
AU  - Thomas,PG
AU  - Xu,J
AU  - Wang,Z
AU  - Chua,BY
AU  - Kedzierska,K
DO  - 10.1016/j.cell.2024.07.026
EP  - 4604
PY  - 2024///
SN  - 0092-8674
SP  - 4586
TI  - High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2024.07.026
UR  - https://www.ncbi.nlm.nih.gov/pubmed/39137778
UR  - https://www.sciencedirect.com/science/article/pii/S0092867424008006?via%3Dihub
VL  - 187
ER  -
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