BibTex format
@article{Suseeladevi:2024:10.1016/j.lanepe.2024.101025,
author = {Suseeladevi, AK and Denholm, R and Retford, M and Raffetti, E and Burden, C and Birchenall, K and Male, V and Walker, V and Tomlinson, C and Wood, AM and Zuccolo, L},
doi = {10.1016/j.lanepe.2024.101025},
journal = {The Lancet Regional Health. Europe},
title = {COVID-19 vaccination and birth outcomes of 186,990 women vaccinated before pregnancy: an England-wide cohort study},
url = {http://dx.doi.org/10.1016/j.lanepe.2024.101025},
volume = {45},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundCOVID-19 vaccination in pregnancy is recommended by the World Health Organisation as effective and safe. However, there remains a lack of robust evidence to inform vaccination choices for women of childbearing potential in relation to their future pregnancies. Here we investigated the association between starting a course of COVID-19 vaccination before pregnancy and birth outcomes.MethodsWe analysed England-wide linked electronic health records for all pregnancies reaching at least 24 weeks gestation between 25th May 2021 and 28th October 2022. We estimated incidence rates and hazard ratios for birth and pregnancy outcomes by pre-pregnancy COVID-19 vaccination status.FindingsBased on 186,990 women, compared to starting a pregnancy unvaccinated, receiving COVID-19 vaccination within 12 months before pregnancy was associated with lower risks of very and extremely preterm birth and small-for-gestational age in term babies for any vaccine type (adjusted hazard ratio and 95% confidence interval: 0.74 [0.63, 0.88] and 0.94 [0.88, 1.00], respectively), and lower stillbirth risk in those receiving an mRNA vaccine (0.72 [0.52, 1.00]). Incidence of venous thromboembolism during pregnancy was higher amongst women receiving a viral-vector, but not an mRNA vaccine (1.54 [1.10, 2.16] and 1.02 [0.70, 1.50], respectively). Results were generally consistent for different dose regimens and across sensitivity analyses.InterpretationWe found evidence that pregnancies starting within 12 months from a first COVID-19 vaccination, compared to those in unvaccinated women, experienced fewer adverse birth outcomes, overall or in selected subgroups of the general population, accounting for potential confounders. An mRNA vaccine should be preferred to a viral-vector vaccine, to minimise safety issues, but where the latter is the only choice, it is still to be preferred to starting a pregnancy unvaccinated. The venous thromboembolism risk of the viral-vector vaccine was substantially l
AU - Suseeladevi,AK
AU - Denholm,R
AU - Retford,M
AU - Raffetti,E
AU - Burden,C
AU - Birchenall,K
AU - Male,V
AU - Walker,V
AU - Tomlinson,C
AU - Wood,AM
AU - Zuccolo,L
DO - 10.1016/j.lanepe.2024.101025
PY - 2024///
SN - 2666-7762
TI - COVID-19 vaccination and birth outcomes of 186,990 women vaccinated before pregnancy: an England-wide cohort study
T2 - The Lancet Regional Health. Europe
UR - http://dx.doi.org/10.1016/j.lanepe.2024.101025
VL - 45
ER -