In this section
@article{Kreuter:2025:10.1016/j.chest.2025.04.003,
author = {Kreuter, M and Maher, TM and Wuyts, WA and Valenzuela, C and Hamblin, M and Kim, S and Patel, A and Elpers, B and Richeldi, L},
doi = {10.1016/j.chest.2025.04.003},
journal = {Chest},
title = {Effect of admilparant, an LPA1 antagonist, on disease progression in pulmonary fibrosis},
url = {http://dx.doi.org/10.1016/j.chest.2025.04.003},
year = {2025}
}
TY - JOUR
AB - BACKGROUNDIdiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF) are chronic fibrosing interstitial lung diseases associated with irreversible loss of lung function and early mortality. Admilparant (BMS-986278) is an oral lysophosphatidic acid receptor 1 (LPA1) antagonist under development for treatment of IPF and PPF.RESEARCH QUESTIONHow does admilparant affect time to disease progression in patients with IPF or PPF?STUDY DESIGN AND METHODSIn a phase 2, randomized, double-blind, placebo-controlled study, parallel cohorts of patients with IPF or PPF were randomized separately 1:1:1 to receive 30-mg admilparant, 60-mg admilparant, or placebo twice daily for 26 weeks; background antifibrotics were allowed. The effect of admilparant vs placebo on time to disease progression was assessed post hoc. Disease progression was defined as a composite of relative decline of ≥10% in percentage of predicted forced vital capacity (ppFVC), acute exacerbation, all-cause hospitalization, and all-cause mortality. Subgroup analyses were performed based on median ppFVC at baseline. A Kaplan-Meier product-limit approach assessed time to first event of disease progression over 26 weeks.RESULTSIn total, 255 patients with IPF and 114 patients with PPF were included. Median ppFVC at baseline was 77.3% and 64.7% in the IPF and PPF cohorts, respectively. Treatment with 60-mg admilparant delayed time to disease progression over 26 weeks compared with placebo in both cohorts of patients (IPF: hazard ratio, 0.54 [95% CI, 0.31-0.95]; PPF: hazard ratio, 0.41 [95% CI, 0.18-0.90]). A similar trend was observed in the subgroup analysis of patients with ppFVC at baseline either below or above the median value. In both cohorts, the most frequent first event was relative decline of ≥10% in ppFVC; no deaths were reported as first progression events.INTERPRETATIONThese findings support further evaluation of admilparant as a therapeutic option for patients with IPF or PPF in phas
AU - Kreuter,M
AU - Maher,TM
AU - Wuyts,WA
AU - Valenzuela,C
AU - Hamblin,M
AU - Kim,S
AU - Patel,A
AU - Elpers,B
AU - Richeldi,L
DO - 10.1016/j.chest.2025.04.003
PY - 2025///
SN - 0012-3692
TI - Effect of admilparant, an LPA1 antagonist, on disease progression in pulmonary fibrosis
T2 - Chest
UR - http://dx.doi.org/10.1016/j.chest.2025.04.003
UR - https://doi.org/10.1016/j.chest.2025.04.003
ER -