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@article{Papargyris:2026,
author = {Papargyris, L and Chiu, C},
journal = {Nature Medicine},
title = {Innate immune responsiveness predicts both enhanced cellular immunity and symptomatic disease after controlled human influenza infection},
year = {2026}
}
TY - JOUR
AB - Controlled human influenza infection studies can uniquely interrogate the early immune factors associated with clinical outcome. Here, 27 healthy volunteers with low strain-specific serum neutralising antibody levels were challenged with influenza A/H3N2 virus. Twenty-two became infected, with 18 developing mild-moderate symptoms while 4 remained asymptomatic. Local and systemic immune profiling revealed innate pathways that engaged more rapidly and to a higher level in symptomatic individuals. Earlier monocyte and dendritic cell activation correlated with higher symptom scores but also enhanced natural killer (NK) and CD8+ T cell activation thereafter. At baseline, peripheral blood mononuclear cells (PBMCs) from symptomatics were more responsive to in vitro challenge, indicating a predisposition to divergent immunological outcomes at the time of virus exposure that was subsequently modulated by infection. These results show that human innate cell responsiveness is a predeterminant of both symptomatic disease and cellular immune responses known to promote viral clearance, suggesting potential targets for therapeutic intervention if decoupled.
AU - Papargyris,L
AU - Chiu,C
PY - 2026///
SN - 1078-8956
TI - Innate immune responsiveness predicts both enhanced cellular immunity and symptomatic disease after controlled human influenza infection
T2 - Nature Medicine
ER -