BibTex format
@article{Thrush:2026,
author = {Thrush, R and Aprile, F},
journal = {Current Opinion in Structural Biology},
title = {The sequence grammar and interactions controlling the aging of protein biomolecular condensates},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Biomolecular condensates play key roles in the cell by organizing and regulating important biochemical processes, including transcriptional regulation, RNA metabolism, ribosome biogenesis, and stress responses. While these assemblies are typically dynamic, they can undergo time-dependent aging into solid assemblies, which has been linked to pathologies including neurodegenerative disease and cancer. In this review, we focus on the mechanisms that drive condensate aging. In particular, we discuss how features of protein sequence, such as amino acid composition, interaction motifs, and post-translational modifications, influence condensate aging. We further highlight how interactions with RNA and lipid membranes modulate condensate behavior by altering interaction networks and interfacial properties.
AU - Thrush,R
AU - Aprile,F
PY - 2026///
SN - 0959-440X
TI - The sequence grammar and interactions controlling the aging of protein biomolecular condensates
T2 - Current Opinion in Structural Biology
ER -