In this section
@article{Openshaw:1988:10.1099/0022-1317-69-2-305,
author = {Openshaw, PJ and Pemberton, RM and Ball, LA and Wertz, GW and Askonas, BA},
doi = {10.1099/0022-1317-69-2-305},
journal = {J Gen Virol},
pages = {305--312},
title = {Helper T cell recognition of respiratory syncytial virus in mice.},
url = {http://dx.doi.org/10.1099/0022-1317-69-2-305},
volume = {69 ( Pt 2)},
year = {1988}
}
TY - JOUR
AB - In this study we aimed to define the protein and viral subtype specificities of helper Th cells to respiratory syncytial virus (RSV). BALB/c mice were primed by infection with RSV, or with vaccinia viruses (VV) containing genes encoding several individual RSV proteins. Priming for Th cell memory was assayed by stimulating spleen cells in vitro with different RSV isolates and measuring RSV-specific interleukin 2 (IL-2) release by T cells into supernatants using an IL-2-dependent CTLL cell line. Splenocytes from mice primed intranasally with RSV exhibited RSV-specific Th cell memory, whereas those from unprimed mice did not. Th cell recognition was in part specific to the strain of RSV used in priming and in part cross-reactive between RSV strains. Intraperitoneal priming with RSV fusion protein-expressing VV or nucleoprotein-expressing VV induced a stronger RSV-specific Th cell response than the attachment glycoprotein-expressing VV which produced only slight Th recognition. No Th cell recognition of two non-structural proteins (1A and 1B) could be demonstrated.
AU - Openshaw,PJ
AU - Pemberton,RM
AU - Ball,LA
AU - Wertz,GW
AU - Askonas,BA
DO - 10.1099/0022-1317-69-2-305
EP - 312
PY - 1988///
SN - 0022-1317
SP - 305
TI - Helper T cell recognition of respiratory syncytial virus in mice.
T2 - J Gen Virol
UR - http://dx.doi.org/10.1099/0022-1317-69-2-305
UR - https://www.ncbi.nlm.nih.gov/pubmed/2963089
VL - 69 ( Pt 2)
ER -