Citation

BibTex format

@article{Sullivan:2003:10.1046/j.1365-3083.2003.01276.x,
author = {Sullivan, AK and Burton, CT and Nelson, MR and Moyle, G and Mandalia, S and Gotch, FM and Gazzard, BG and Imami, N},
doi = {10.1046/j.1365-3083.2003.01276.x},
journal = {Scandinavian Journal of Immunology},
pages = {600--607},
title = {Restoration of human immunodeficiency virus-1-specific responses in patients changing from protease to non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy},
url = {http://dx.doi.org/10.1046/j.1365-3083.2003.01276.x},
volume = {57},
year = {2003}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The effect of altering antiretroviral therapy (ART) on responses to viral, recall and human immunodeficiency virus (HIV)-1-specific recombinant antigens and interleukin-2 (IL-2) in HIV-1-infected patients was assessed. A longitudinal cohort study in eight HIV-1 infected individuals following a clinically indicated therapy change (seven for drug intolerance and one for virological failure) from protease inhibitor (PI) to non-nucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral regimens was performed. CD4 T-cell counts, viral loads, lymphoproliferative responses, cytokine production and latent proviral deoxyribonucleic acid (DNA) were measured at baseline and at weeks 12 and 24 after therapy substitution. Following therapy-switch there was a 33% proportional increase in mitogen response (95% confidence interval (CI), 3–33%) and a 31% increase (95% CI, 15–48%) in viral and recall-antigen responses. Six patients developed proliferative responses to low concentration IL-2 stimulation. All patients demonstrated an increase in median HIV-1-specific responses, as three had detectable virus at baseline (two being viral rebound); this may reflect an autovaccination effect. Proviral DNA changes largely reflected plasma HIV-1 ribonucleic acid (RNA). In conclusion, NNRTI substitution for a PI may favour immune reconstitution with an improvement in HIV-1-specific responses, which may reflect differential effects on antigen processing and presentation, an autovaccination effect or alternatively a potential suppressive effect of the PI.
AU  - Sullivan,AK
AU  - Burton,CT
AU  - Nelson,MR
AU  - Moyle,G
AU  - Mandalia,S
AU  - Gotch,FM
AU  - Gazzard,BG
AU  - Imami,N
DO  - 10.1046/j.1365-3083.2003.01276.x
EP  - 607
PY  - 2003///
SN  - 0300-9475
SP  - 600
TI  - Restoration of human immunodeficiency virus-1-specific responses in patients changing from protease to non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy
T2  - Scandinavian Journal of Immunology
UR  - http://dx.doi.org/10.1046/j.1365-3083.2003.01276.x
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183367900013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-3083.2003.01276.x
VL  - 57
ER  -
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