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@article{Paternoster:2011:10.1038/ng.1017,
author = {Paternoster, L and Standl, M and Chen, CM and Ramasamy, A and Bonnelykke, K and Duijts, L and Ferreira, MA and Alves, AC and Thyssen, JP and Albrecht, E and Baurecht, H and Feenstra, B and Sleiman, PM and Hysi, P and Warrington, NM and Curjuric, I and Myhre, R and Curtin, JA and Groen-Blokhuis, MM and Kerkhof, M and Saaf, A and Franke, A and Ellinghaus, D and Folster-Holst, R and Dermitzakis, E and Montgomery, SB and Prokisch, H and Heim, K and Hartikainen, AL and Pouta, A and Pekkanen, J and Blakemore, AI and Buxton, JL and Kaakinen, M and Duffy, DL and Madden, PA and Heath, AC and Montgomery, GW and Thompson, PJ and Matheson, MC and Le, Souef P and St, Pourcain B and Smith, GD and Henderson, J and Kemp, JP and Timpson, NJ and Deloukas, P and Ring, SM and Wichmann, HE and Muller-Nurasyid, M and Novak, N and Klopp, N and Rodriguez, E and McArdle, W and Linneberg, A and Menne, T and Nohr, EA and Hofman, A and Uitterlinden, AG and van, Duijn CM and Rivadeneira, F and de, Jongste JC and v},
doi = {10.1038/ng.1017},
journal = {Nature Genetics},
pages = {187--192},
title = {Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis},
url = {http://dx.doi.org/10.1038/ng.1017},
volume = {44},
year = {2011}
}
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TY  - JOUR
AB  - Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 x 10(-13)) and rs2164983 near ACTL9 (OR = 1.16, P = 7.1 x 10(-9)), both of which are near genes that have been implicated in epidermal proliferation and differentiation, as well as rs2897442 in KIF3A within the cytokine cluster at 5q31.1 (OR = 1.11, P = 3.8 x 10(-8)). We also replicated association with the FLG locus and with two recently identified association signals at 11q13.5 (rs7927894; P = 0.008) and 20q13.33 (rs6010620; P = 0.002). Our results underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis.
AU  - Paternoster,L
AU  - Standl,M
AU  - Chen,CM
AU  - Ramasamy,A
AU  - Bonnelykke,K
AU  - Duijts,L
AU  - Ferreira,MA
AU  - Alves,AC
AU  - Thyssen,JP
AU  - Albrecht,E
AU  - Baurecht,H
AU  - Feenstra,B
AU  - Sleiman,PM
AU  - Hysi,P
AU  - Warrington,NM
AU  - Curjuric,I
AU  - Myhre,R
AU  - Curtin,JA
AU  - Groen-Blokhuis,MM
AU  - Kerkhof,M
AU  - Saaf,A
AU  - Franke,A
AU  - Ellinghaus,D
AU  - Folster-Holst,R
AU  - Dermitzakis,E
AU  - Montgomery,SB
AU  - Prokisch,H
AU  - Heim,K
AU  - Hartikainen,AL
AU  - Pouta,A
AU  - Pekkanen,J
AU  - Blakemore,AI
AU  - Buxton,JL
AU  - Kaakinen,M
AU  - Duffy,DL
AU  - Madden,PA
AU  - Heath,AC
AU  - Montgomery,GW
AU  - Thompson,PJ
AU  - Matheson,MC
AU  - Le,Souef P
AU  - St,Pourcain B
AU  - Smith,GD
AU  - Henderson,J
AU  - Kemp,JP
AU  - Timpson,NJ
AU  - Deloukas,P
AU  - Ring,SM
AU  - Wichmann,HE
AU  - Muller-Nurasyid,M
AU  - Novak,N
AU  - Klopp,N
AU  - Rodriguez,E
AU  - McArdle,W
AU  - Linneberg,A
AU  - Menne,T
AU  - Nohr,EA
AU  - Hofman,A
AU  - Uitterlinden,AG
AU  - van,Duijn CM
AU  - Rivadeneira,F
AU  - de,Jongste JC
AU  - van,der Valk RJ
AU  - Wjst,M
AU  - Jogi,R
AU  - Geller,F
AU  - Boyd,HA
AU  - Murray,JC
AU  - Kim,C
AU  - Mentch,F
AU  - March,M
AU  - Mangino,M
AU  - Spector,TD
AU  - Bataille,V
AU  - Pennell,CE
AU  - Holt,PG
AU  - Sly,P
AU  - Tiesler,CM
AU  - Thiering,E
AU  - Illig,T
AU  - Imboden,M
AU  - Nystad,W
AU  - Simpson,A
AU  - Hottenga,JJ
AU  - Postma,D
AU  - Koppelman,GH
AU  - Smit,HA
AU  - Soderhall,C
AU  - Chawes,B
AU  - Kreiner-Moller,E
AU  - Bisgaard,H
AU  - Melen,E
AU  - Boomsma,DI
AU  - Custovic,A
AU  - Jacobsson,B
AU  - Probst-Hensch,NM
AU  - Palmer,LJ
AU  - Glass,D
AU  - Hakonarson,H
AU  - Melbye,M
DO  - 10.1038/ng.1017
EP  - 192
PY  - 2011///
SN  - 1546-1718
SP  - 187
TI  - Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/ng.1017
VL  - 44
ER  -
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