Citation

BibTex format

@article{Gurung:2014:10.4049/jimmunol.1302839,
author = {Gurung, P and Anand, PK and Malireddi, RKS and Walle, LV and Van, Opdenbosch N and Dillon, CP and Weinlich, R and Green, DR and Lamkanfi, M and Kanneganti, T-D},
doi = {10.4049/jimmunol.1302839},
journal = {Journal of Immunology},
pages = {1835--1846},
title = {FADD and caspase-8 mediate priming and  activation of the canonical and noncanonical Nlrp3 inflammasomes},
url = {http://dx.doi.org/10.4049/jimmunol.1302839},
volume = {192},
year = {2014}
}
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TY  - JOUR
AB  - The Nlrp3 inflammasome is critical for host immunity, but the mechanisms controlling its activation are enigmatic. In this study, we show that loss of FADD or caspase-8 in a RIP3-deficient background, but not RIP3 deficiency alone, hampered transcriptional priming and posttranslational activation of the canonical and noncanonical Nlrp3 inflammasome. Deletion of caspase-8 in the presence or absence of RIP3 inhibited caspase-1 and caspase-11 activation by Nlrp3 stimuli but not the Nlrc4 inflammasome. In addition, FADD deletion prevented caspase-8 maturation, positioning FADD upstream of caspase-8. Consequently, FADD- and caspase-8–deficient mice had impaired IL-1β production when challenged with LPS or infected with the enteropathogen Citrobacter rodentium. Thus, our results reveal FADD and caspase-8 as apical mediators of canonical and noncanonical Nlrp3 inflammasome priming and activation.
AU  - Gurung,P
AU  - Anand,PK
AU  - Malireddi,RKS
AU  - Walle,LV
AU  - Van,Opdenbosch N
AU  - Dillon,CP
AU  - Weinlich,R
AU  - Green,DR
AU  - Lamkanfi,M
AU  - Kanneganti,T-D
DO  - 10.4049/jimmunol.1302839
EP  - 1846
PY  - 2014///
SN  - 0022-1767
SP  - 1835
TI  - FADD and caspase-8 mediate priming and  activation of the canonical and noncanonical Nlrp3 inflammasomes
T2  - Journal of Immunology
UR  - http://dx.doi.org/10.4049/jimmunol.1302839
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000331267200051&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.jimmunol.org/content/192/4/1835
VL  - 192
ER  -
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