BibTex format
@article{Felix:2015:hmg/ddv472,
author = {Felix, JF and Bradfield, JP and Monnereau, C and van, der Valk RJ and Stergiakouli, E and Chesi, A and Gaillard, R and Feenstra, B and Thiering, E and Kreiner-Møller, E and Mahajan, A and Pitkänen, N and Joro, R and Cavadino, A and Huikari, V and Franks, S and Groen-Blokhuis, MM and Cousminer, DL and Marsh, JA and Lehtimäki, T and Curtin, JA and Vioque, J and Ahluwalia, TS and Myhre, R and Price, TS and Vilor-Tejedor, N and Yengo, L and Grarup, N and Ntalla, I and Ang, W and Atalay, M and Bisgaard, H and Blakemore, AI and Bonnefond, A and Carstensen, L and Bone, Mineral Density in Childhood Study BMDCS and Early, Genetics and Lifecourse Epidemiology EAGLE consortium and Eriksson, J and Flexeder, C and Franke, L and Geller, F and Geserick, M and Hartikainen, AL and Haworth, CM and Hirschhorn, JN and Hofman, A and Holm, JC and Horikoshi, M and Hottenga, JJ and Huang, J and Kadarmideen, HN and Kähönen, M and Kiess, W and Lakka, HM and Lakka, TA and Lewin, AM and Liang, L and Lyytikäinen, },
doi = {hmg/ddv472},
journal = {Human Molecular Genetics},
pages = {389--403},
title = {Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.},
url = {http://dx.doi.org/10.1093/hmg/ddv472},
volume = {25},
year = {2015}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10(-10)) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index.
AU - Felix,JF
AU - Bradfield,JP
AU - Monnereau,C
AU - van,der Valk RJ
AU - Stergiakouli,E
AU - Chesi,A
AU - Gaillard,R
AU - Feenstra,B
AU - Thiering,E
AU - Kreiner-Møller,E
AU - Mahajan,A
AU - Pitkänen,N
AU - Joro,R
AU - Cavadino,A
AU - Huikari,V
AU - Franks,S
AU - Groen-Blokhuis,MM
AU - Cousminer,DL
AU - Marsh,JA
AU - Lehtimäki,T
AU - Curtin,JA
AU - Vioque,J
AU - Ahluwalia,TS
AU - Myhre,R
AU - Price,TS
AU - Vilor-Tejedor,N
AU - Yengo,L
AU - Grarup,N
AU - Ntalla,I
AU - Ang,W
AU - Atalay,M
AU - Bisgaard,H
AU - Blakemore,AI
AU - Bonnefond,A
AU - Carstensen,L
AU - Bone,Mineral Density in Childhood Study BMDCS
AU - Early,Genetics and Lifecourse Epidemiology EAGLE consortium
AU - Eriksson,J
AU - Flexeder,C
AU - Franke,L
AU - Geller,F
AU - Geserick,M
AU - Hartikainen,AL
AU - Haworth,CM
AU - Hirschhorn,JN
AU - Hofman,A
AU - Holm,JC
AU - Horikoshi,M
AU - Hottenga,JJ
AU - Huang,J
AU - Kadarmideen,HN
AU - Kähönen,M
AU - Kiess,W
AU - Lakka,HM
AU - Lakka,TA
AU - Lewin,AM
AU - Liang,L
AU - Lyytikäinen,LP
AU - Ma,B
AU - Magnus,P
AU - McCormack,SE
AU - McMahon,G
AU - Mentch,FD
AU - Middeldorp,CM
AU - Murray,CS
AU - Pahkala,K
AU - Pers,TH
AU - Pfäffle,R
AU - Postma,DS
AU - Power,C
AU - Simpson,A
AU - Sengpiel,V
AU - Tiesler,CM
AU - Torrent,M
AU - Uitterlinden,AG
AU - van,Meurs JB
AU - Vinding,R
AU - Waage,J
AU - Wardle,J
AU - Zeggini,E
AU - Zemel,BS
AU - Dedoussis,GV
AU - Pedersen,O
AU - Froguel,P
AU - Sunyer,J
AU - Plomin,R
AU - Jacobsson,B
AU - Hansen,T
AU - Gonzalez,JR
AU - Custovic,A
AU - Raitakari,OT
AU - Pennell,CE
AU - Widén,E
AU - Boomsma,DI
AU - Koppelman,GH
AU - Sebert,S
AU - Järvelin,MR
AU - Hyppönen,E
AU - McCarthy,MI
AU - Lindi,V
AU - Harri,N
AU - Körner,A
AU - Bønnelykke,K
AU - Heinrich,J
AU - Melbye,M
AU - Rivadeneira,F
AU - Hakonarson,H
AU - Ring,SM
AU - Smith,GD
AU - Sørensen,TI
AU - Timpson,NJ
AU - Grant,SF
AU - Jaddoe,VW
AU - Early,Growth Genetics EGG Consortium
AU - Bone,Mineral Density in Childhood Study BMDCS
DO - hmg/ddv472
EP - 403
PY - 2015///
SN - 1460-2083
SP - 389
TI - Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
T2 - Human Molecular Genetics
UR - http://dx.doi.org/10.1093/hmg/ddv472
VL - 25
ER -