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@article{Muthuri:2015:10.1111/irv.12363,
author = {Muthuri, SG and Venkatesan, S and Myles, PR and Leonardi-Bee, J and Lim, WS and Mamun, AA and Anovadiya, AP and Araújo, WN and Azziz-Baumgartner, E and Báez, C and Bantar, C and Barhoush, MM and Bassetti, M and Beovic, B and Bingisser, R and Bonmarin, I and Borja-Aburto, VH and Cao, B and Carratala, J and Cuezzo, MR and Denholm, JT and Dominguez, SR and Duarte, PA and Dubnov-Raz, G and Echavarria, M and Fanella, S and Fraser, J and Gao, Z and Gérardin, P and Giannella, M and Gubbels, S and Herberg, J and Iglesias, AL and Hoeger, PH and Hoffmann, M and Hu, X and Islam, QT and Jiménez, MF and Kandeel, A and Keijzers, G and Khalili, H and Khandaker, G and Knight, M and Kusznierz, G and Kuzman, I and Kwan, AM and Amine, IL and Langenegger, E and Lankarani, KB and Leo, YS and Linko, R and Liu, P and Madanat, F and Manabe, T and Mayo-Montero, E and McGeer, A and Memish, ZA and Metan, G and Miki, D and Mohn, KG and Moradi, A and Nymadawa, P and Ozbay, B and Ozkan, M and Parekh, D and Paul, M },
doi = {10.1111/irv.12363},
journal = {Influenza and Other Respiratory Viruses},
pages = {192--204},
title = {Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an IPD meta-analysis.},
url = {http://dx.doi.org/10.1111/irv.12363},
volume = {10},
year = {2015}
}
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TY  - JOUR
AB  - BACKGROUND: The impact of neuraminidase inhibitors (NAIs) on Influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. METHODS: A worldwide meta-analysis of individual participant data (IPD) from 20,634 hospitalised patients with laboratory confirmed A(H1N1)pdm09 (n=20,021) or clinically diagnosed (n=613) 'pandemic influenza'. The primary outcome was radiologically confirmed influenza-related pneumonia (IRP). Odds ratios (OR) were estimated using generalized linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. RESULTS: Among 20,634 included participants, 5,978 (29.0%) had IRP; conversely, 3,349 (16.2%) had confirmed absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0.83 (95%CI 0.64 - 1.06; p=0.136)]. Among the 5,978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR=0.72 (0.44-1.17; p=0.180)] or likelihood of requiring ventilatory support [adj. OR=1.17 (0.71-1.92; p=0.537)]; but early treatment versus later significantly reduced mortality [adj. OR=0.70 (0.55-0.88; p=0.003)] and likelihood of requiring ventilatory support [adj. OR=0.68 (0.54-0.85; p=0.001)]. CONCLUSIONS: Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support. This article is protected by copyright. All rights reserved.
AU  - Muthuri,SG
AU  - Venkatesan,S
AU  - Myles,PR
AU  - Leonardi-Bee,J
AU  - Lim,WS
AU  - Mamun,AA
AU  - Anovadiya,AP
AU  - Araújo,WN
AU  - Azziz-Baumgartner,E
AU  - Báez,C
AU  - Bantar,C
AU  - Barhoush,MM
AU  - Bassetti,M
AU  - Beovic,B
AU  - Bingisser,R
AU  - Bonmarin,I
AU  - Borja-Aburto,VH
AU  - Cao,B
AU  - Carratala,J
AU  - Cuezzo,MR
AU  - Denholm,JT
AU  - Dominguez,SR
AU  - Duarte,PA
AU  - Dubnov-Raz,G
AU  - Echavarria,M
AU  - Fanella,S
AU  - Fraser,J
AU  - Gao,Z
AU  - Gérardin,P
AU  - Giannella,M
AU  - Gubbels,S
AU  - Herberg,J
AU  - Iglesias,AL
AU  - Hoeger,PH
AU  - Hoffmann,M
AU  - Hu,X
AU  - Islam,QT
AU  - Jiménez,MF
AU  - Kandeel,A
AU  - Keijzers,G
AU  - Khalili,H
AU  - Khandaker,G
AU  - Knight,M
AU  - Kusznierz,G
AU  - Kuzman,I
AU  - Kwan,AM
AU  - Amine,IL
AU  - Langenegger,E
AU  - Lankarani,KB
AU  - Leo,YS
AU  - Linko,R
AU  - Liu,P
AU  - Madanat,F
AU  - Manabe,T
AU  - Mayo-Montero,E
AU  - McGeer,A
AU  - Memish,ZA
AU  - Metan,G
AU  - Miki,D
AU  - Mohn,KG
AU  - Moradi,A
AU  - Nymadawa,P
AU  - Ozbay,B
AU  - Ozkan,M
AU  - Parekh,D
AU  - Paul,M
AU  - Poeppl,W
AU  - Polack,FP
AU  - Rath,BA
AU  - Rodríguez,AH
AU  - Siqueira,MM
AU  - Skrt-Magiero,J
AU  - Talarek,E
AU  - Tang,JW
AU  - Torres,A
AU  - Törün,SH
AU  - Tran,D
AU  - Uyeki,TM
AU  - van,Zwol A
AU  - Vaudry,W
AU  - Velyvyte,D
AU  - Vidmar,T
AU  - Zarogoulidis,P
AU  - PRIDE,Consortium Investigators
AU  - Nguyen-Van-Tam,JS
DO  - 10.1111/irv.12363
EP  - 204
PY  - 2015///
SN  - 1750-2659
SP  - 192
TI  - Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an IPD meta-analysis.
T2  - Influenza and Other Respiratory Viruses
UR  - http://dx.doi.org/10.1111/irv.12363
VL  - 10
ER  -
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