BibTex format
@article{May:2016:10.1097/QAD.0000000000000941,
author = {May, MT and Gill, MJ and Wittkop, L and Klein, M and Sabin, C and Harrigan, PR and Dunn, D and Vehreschild, JJ and Rubio, R and Mocroft, A and Cavassini, M and Reiss, P and Monforte, AD and Zangerle, R and Ingle, SM and Hill, T and Jose, S and Sterne, JAC and Boulle, A and Stephan, C and Miro, JM and Cavassini, M and Chene, G-V and Costagliola, D and Dabis, F and Monforte, AD and del, Amo J and Van, Sighem A and Vehreschild, J and Gill, J and Guest, J and Haerry, DH-U and Hogg, R and Justice, A and Mocroft, A and Obel, N and Crane, H and Smith, C and Reiss, P and Saag, M and Sterling, T and Teira, R and Williams, M and Zangerle, R and Sterne, J and May, M and Ingle, S and Trickey, A and Ainsworth, J and Anderson, J and Babiker, A and Chadwick, D and Delpech, V and Dunn, D and Fisher, M and Gazzard, B and Gilson, R and Hay, P and Gompels, M and Hill, T and Johnson, M and Jose, S and Kegg, S and Leen, C and Mackie, N and Nelson, M and Orkin, C and Palfreeman, A and Phillips, A and Pillay},
doi = {10.1097/QAD.0000000000000941},
journal = {AIDS},
pages = {503--513},
title = {Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis},
url = {http://dx.doi.org/10.1097/QAD.0000000000000941},
volume = {30},
year = {2016}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Objectives: To estimate prognosis by viral subtype in HIV-1-infected individuals fromstart of antiretroviral therapy (ART) and after viral failure.Design: Collaborative analysis of data from eight European and three Canadiancohorts.Methods: Adults (N>20 000) who started triple ART between 1996 and 2012 andhad data on viral subtype were followed for mortality. We estimated crude andadjusted (for age, sex, regimen, CD4þ cell count, and AIDS at baseline, period ofstarting ART, stratified by cohort, region of origin and risk group) mortality hazardratios (MHR) by subtype. We estimated MHR subsequent to viral failure defined astwo HIV-RNA measurements greater than 500 copies/ml after achieving viralsuppression.Results: The most prevalent subtypes were B (15 419; 74%), C (2091; 10%), CRF02AG(1057; 5%), A (873; 4%), CRF01AE (506; 2.4%), G (359; 1.7%), and D (232; 1.1%).Subtypes were strongly patterned by region of origin and risk group. During 104 649person-years of observation, 1172/20 784 patients died. Compared with subtype B,mortality was higher for subtype A, but similar for all other subtypes. MHR for A versus Bwere 1.13 (95% confidence interval 0.85,1.50) when stratified by cohort, increased to1.78 (1.27,2.51) on stratification by region and risk, and attenuated to 1.59 (1.14,2.23)on adjustment for covariates. MHR for A versus B was 2.65 (1.64,4.28) and 0.95(0.57,1.57) for patients who started ART with CD4þ cell count below, or more than, 100cells/ml, respectively. There was no difference in mortality between subtypes A, B and Cafter viral failure.Conclusion: Patients with subtype A had worse prognosis, an observation which maybe confounded by socio-demographic factors.
AU - May,MT
AU - Gill,MJ
AU - Wittkop,L
AU - Klein,M
AU - Sabin,C
AU - Harrigan,PR
AU - Dunn,D
AU - Vehreschild,JJ
AU - Rubio,R
AU - Mocroft,A
AU - Cavassini,M
AU - Reiss,P
AU - Monforte,AD
AU - Zangerle,R
AU - Ingle,SM
AU - Hill,T
AU - Jose,S
AU - Sterne,JAC
AU - Boulle,A
AU - Stephan,C
AU - Miro,JM
AU - Cavassini,M
AU - Chene,G-V
AU - Costagliola,D
AU - Dabis,F
AU - Monforte,AD
AU - del,Amo J
AU - Van,Sighem A
AU - Vehreschild,J
AU - Gill,J
AU - Guest,J
AU - Haerry,DH-U
AU - Hogg,R
AU - Justice,A
AU - Mocroft,A
AU - Obel,N
AU - Crane,H
AU - Smith,C
AU - Reiss,P
AU - Saag,M
AU - Sterling,T
AU - Teira,R
AU - Williams,M
AU - Zangerle,R
AU - Sterne,J
AU - May,M
AU - Ingle,S
AU - Trickey,A
AU - Ainsworth,J
AU - Anderson,J
AU - Babiker,A
AU - Chadwick,D
AU - Delpech,V
AU - Dunn,D
AU - Fisher,M
AU - Gazzard,B
AU - Gilson,R
AU - Hay,P
AU - Gompels,M
AU - Hill,T
AU - Johnson,M
AU - Jose,S
AU - Kegg,S
AU - Leen,C
AU - Mackie,N
AU - Nelson,M
AU - Orkin,C
AU - Palfreeman,A
AU - Phillips,A
AU - Pillay,D
AU - Post,F
AU - Sabin,C
AU - Sachikonye,M
AU - Schwenk,A
AU - Walsh,J
AU - Thornton,A
AU - Huntington,S
AU - Glabay,A
AU - Orkin,C
AU - Garrett,N
AU - Lynch,J
AU - Hand,J
AU - de,Souza C
AU - Fisher,M
AU - Perry,N
AU - Tilbury,S
AU - Youssef,E
AU - Churchill,D
AU - Gazzard,B
AU - Nelson,M
AU - Waxman,M
AU - Asboe,D
AU - Mandalia,S
AU - Anderson,J
AU - Munshi,S
AU - Awosika,D
AU - Post,F
AU - Korat,H
AU - Taylor,C
AU - Gleisner,Z
AU - Ibrahim,F
AU - Campbell,L
AU - Babiker,A
AU - Dunn,D
AU - Glabay,A
AU - Chadwick,D
AU - Baillie,K
AU - Cope,E
AU - Gibney,M
AU - Gibson,J
AU - Gilson,R
AU - Brima,N
AU - Williams,I
AU - Ainsworth,J
AU - Schwenk,A
AU - Miller,S
AU - Wood,C
AU - Johnson,M
AU - Youle,M
AU - Lampe,F
AU - Smith,C
AU - Chaloner,C
AU - Hill,T
AU - Huntington,S
AU - Jose,S
AU - Phillips,A
AU - Sabin,C
AU - Thornton,A
AU - Walsh,J
AU - Mackie,N
AU - Winston,A
AU - Weber,J
AU - Ramzan,F
AU - Carder,M
AU - Leen,C
AU - Wilson,A
AU - Morris,S
AU - Gompels,M
AU - Allan,S
AU - Palfreeman,A
AU - Moore,A
AU - Fox,L
AU - Bojanowski,J
AU - Lewszuk,A
AU - Kegg,S
AU - Main,P
AU - Mitchell,D
AU - Hunter,D
AU - Sachikonye,M
AU - Hay,P
AU - Dhillon,M
AU - Martin,F
AU - Douglas,S
AU - Russell-Sharp,S
DO - 10.1097/QAD.0000000000000941
EP - 513
PY - 2016///
SN - 0269-9370
SP - 503
TI - Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis
T2 - AIDS
UR - http://dx.doi.org/10.1097/QAD.0000000000000941
VL - 30
ER -