BibTex format
@article{Roberts:2016:10.1111/all.12939,
author = {Roberts, G and Ollert, M and Aalberse, R and Austin, M and Custovic, A and DunnGalvin, A and Eigenmann, PA and Fassio, F and Grattan, C and Hellings, P and Hourihane, J and Knol, E and Muraro, A and Papadopoulos, N and Santos, AF and Schnadt, S and Tzeli, K},
doi = {10.1111/all.12939},
journal = {Allergy},
pages = {1540--1551},
title = {A new framework for the interpretation of IgE sensitization tests},
url = {http://dx.doi.org/10.1111/all.12939},
volume = {71},
year = {2016}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - IgE sensitization tests, such as skin prick testing and serum specific IgE, have been used to diagnose IgE-mediated clinical allergy for many years. Their prime drawback is that they detect sensitization which is only loosely related to clinical allergy. Many patients therefore require provocation tests to make a definitive diagnosis; these are often expensive and potentially associated with severe reactions. The likelihood of clinical allergy can be semi-quantified from an IgE sensitization test results. This relationship varies though according to the patients’ age, ethnicity, nature of the putative allergic reaction and co-existing clinical diseases such as eczema. The likelihood of clinical allergy can be more precisely estimated from an IgE sensitization test result, by taking into account the patient's presenting features (pre-test probability). The presence of each of these patient specific factors may mean that a patient is more or less likely to have clinically allergy with a given test result (post-test probability). We present two approaches to including pre-test probabilities in the interpretation of results. These approaches are currently limited by a lack of data to allow us to derive pre-test probabilities for diverse setting, regions and allergens. Also, co-factors, such as exercise, may be necessary for exposure to an allergen to result in an allergic reaction in specific IgE positive patients. The diagnosis of IgE-mediated allergy is now being aided by the introduction of allergen component testing which may identify clinically relevant sensitization. Other approaches are in development with basophil activation testing being closest to clinical application.
AU - Roberts,G
AU - Ollert,M
AU - Aalberse,R
AU - Austin,M
AU - Custovic,A
AU - DunnGalvin,A
AU - Eigenmann,PA
AU - Fassio,F
AU - Grattan,C
AU - Hellings,P
AU - Hourihane,J
AU - Knol,E
AU - Muraro,A
AU - Papadopoulos,N
AU - Santos,AF
AU - Schnadt,S
AU - Tzeli,K
DO - 10.1111/all.12939
EP - 1551
PY - 2016///
SN - 1398-9995
SP - 1540
TI - A new framework for the interpretation of IgE sensitization tests
T2 - Allergy
UR - http://dx.doi.org/10.1111/all.12939
VL - 71
ER -