BibTex format
@article{Irshad:2017:10.1158/0008-5472.CAN-16-0598,
author = {Irshad, S and Flores-Borja, F and Lawler, K and Monypenny, J and Evans, R and Male, V and Gordon, P and Cheung, A and Gazinska, P and Noor, F and Wong, F and Grigoriadis, A and Fruhwirth, GO and Barber, PR and Woodman, N and Patel, D and Rodriguez-Justo, M and Owen, J and Martin, SG and Pinder, SE and Gillett, CE and Poland, SP and Ameer-Beg, S and McCaughan, F and Carlin, LM and Hasan, U and Withers, DR and Lane, P and Vojnovic, B and Quezada, SA and Ellis, P and Tutt, ANJ and Ng, T},
doi = {10.1158/0008-5472.CAN-16-0598},
journal = {Cancer Research},
pages = {1083--1096},
title = {ROR gamma t(+) innate lymphoid cells promote lymph node metastasis of breast cancers},
url = {http://dx.doi.org/10.1158/0008-5472.CAN-16-0598},
volume = {77},
year = {2017}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the presence of increased numbers of RORγt+ group 3 innate lymphoid cells (ILC3) correlates with an increased likelihood of lymph node metastasis. In a preclinical mouse model of breast cancer, CCL21-mediated recruitment of ILC3 to tumors stimulated the production of the CXCL13 by TME stromal cells, which in turn promoted ILC3–stromal interactions and production of the cancer cell motile factor RANKL. Depleting ILC3 or neutralizing CCL21, CXCL13, or RANKL was sufficient to decrease lymph node metastasis. Our findings establish a role for RORγt+ILC3 in promoting lymphatic metastasis by modulating the local chemokine milieu of cancer cells in the TME. Cancer Res; 77(5); 1083–96.
AU - Irshad,S
AU - Flores-Borja,F
AU - Lawler,K
AU - Monypenny,J
AU - Evans,R
AU - Male,V
AU - Gordon,P
AU - Cheung,A
AU - Gazinska,P
AU - Noor,F
AU - Wong,F
AU - Grigoriadis,A
AU - Fruhwirth,GO
AU - Barber,PR
AU - Woodman,N
AU - Patel,D
AU - Rodriguez-Justo,M
AU - Owen,J
AU - Martin,SG
AU - Pinder,SE
AU - Gillett,CE
AU - Poland,SP
AU - Ameer-Beg,S
AU - McCaughan,F
AU - Carlin,LM
AU - Hasan,U
AU - Withers,DR
AU - Lane,P
AU - Vojnovic,B
AU - Quezada,SA
AU - Ellis,P
AU - Tutt,ANJ
AU - Ng,T
DO - 10.1158/0008-5472.CAN-16-0598
EP - 1096
PY - 2017///
SN - 0008-5472
SP - 1083
TI - ROR gamma t(+) innate lymphoid cells promote lymph node metastasis of breast cancers
T2 - Cancer Research
UR - http://dx.doi.org/10.1158/0008-5472.CAN-16-0598
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396011100005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://cancerres.aacrjournals.org/content/77/5/1083
VL - 77
ER -