In this section
@inproceedings{Durham:1991:10.1111/j.1365-2222.1991.tb01729.x,
author = {Durham, SR and Varney, V and Gaga, M and Frew, AJ and Jacobson, M and Kay, AB},
doi = {10.1111/j.1365-2222.1991.tb01729.x},
pages = {206--210},
title = {Immunotherapy and allergic inflammation.},
url = {http://dx.doi.org/10.1111/j.1365-2222.1991.tb01729.x},
year = {1991}
}
TY - CPAPER
AB - A double-blind placebo-controlled trial of allergen injection immunotherapy in adult patients with severe summer hayfever. We used a partially purified biologically standardised grass pollen depot preparation (Alutard SQ, ALK Denmark Ltd.). Immunotherapy was extremely effective in reducing symptoms and medication requirements. Clinical improvement was accompanied by a decrease in both a target organ (conjunctival) and skin sensitivity. The injections were well-tolerated with minimal side effects. The results suggest that 30 minutes rather than 2 hours is an acceptable post-injection observation period. Successful immunotherapy was accompanied by suppression of the late cutaneous response to allergen. Specific immunostaining of skin biopsies revealed inhibition of the characteristic CD4+ T cell and EG2+ activated eosinophil cellular infiltrate during the late response. There was a significant relationship between CD4+ T cell and eosinophil counts after immunotherapy, i.e. the lower the number of infiltrating CD4+ cells, the lower the eosinophil counts. An unexpected finding was a prominent CD25+ (interleukin-2 receptor positive) cellular infiltrate which was only observed following Alutard SQ. Further studies involving double immunostaining methods should identify the phenotype of these activated, IL-2R+ cells. Based on murine studies Mosmann and colleagues have classified T cell responses into two types according to their profile of lymphokine production [11]. TH1 cells produce predominantly the IL-4 family of cytokines (IL-3, IL-4, IL-5) whereas TH2 cells produce predominantly interleukin-2 and interferon gamma. Insofar as the Mosmann classification may possibly be relevant to human T cell responses, the above findings would support a switch from a "TH2-" to a "TH1-" lymphocyte response following immunotherapy.(ABSTRACT TRUNCATED AT 250 WORDS)
AU - Durham,SR
AU - Varney,V
AU - Gaga,M
AU - Frew,AJ
AU - Jacobson,M
AU - Kay,AB
DO - 10.1111/j.1365-2222.1991.tb01729.x
EP - 210
PY - 1991///
SN - 0954-7894
SP - 206
TI - Immunotherapy and allergic inflammation.
UR - http://dx.doi.org/10.1111/j.1365-2222.1991.tb01729.x
UR - https://www.ncbi.nlm.nih.gov/pubmed/2032147
ER -