BibTex format
@article{Stasi:2008:10.1182/blood-2007-12-129262,
author = {Stasi, R and Cooper, N and Del, Poeta G and Stipa, E and Laura, Evangelista M and Abruzzese, E and Amadori, S},
doi = {10.1182/blood-2007-12-129262},
journal = {Blood},
pages = {1147--1150},
title = {Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell–depleting therapy with rituximab},
url = {http://dx.doi.org/10.1182/blood-2007-12-129262},
volume = {112},
year = {2008}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - <jats:title>Abstract</jats:title> <jats:p>The effects of B-cell depletion with rituximab on regulatory T cells (Tregs) have not been determined. We investigated Tregs in patients receiving rituximab for chronic idiopathic thrombocytopenic purpura (ITP). The peripheral blood Tregs, identified as CD4+FOXP3+ T cells, were measured by flow cytometry prior to and after the immunotherapy. In addition, Tregs were analyzed for their usage of the T-cell receptor (TCR) β-variable (VB) region gene as well as their regulatory function as assessed by cell proliferation assays. Pretreatment data revealed a reduced number and a defective suppressive capacity of Tregs in ITP patients compared with control individuals. In addition, Tregs showed a polyclonal spectratype. Patients, particularly responders, showed restored numbers of Tregs as well as a restored regulatory function upon treatment with rituximab. These results indicate that patients with active ITP have a defective T regulatory cell compartment that can be modulated by a B cell–targeted therapy.</jats:p>
AU - Stasi,R
AU - Cooper,N
AU - Del,Poeta G
AU - Stipa,E
AU - Laura,Evangelista M
AU - Abruzzese,E
AU - Amadori,S
DO - 10.1182/blood-2007-12-129262
EP - 1150
PY - 2008///
SN - 0006-4971
SP - 1147
TI - Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell–depleting therapy with rituximab
T2 - Blood
UR - http://dx.doi.org/10.1182/blood-2007-12-129262
UR - https://doi.org/10.1182/blood-2007-12-129262
VL - 112
ER -