In this section
@article{Cooper:2006:10.1182/blood-2005-05-1819,
author = {Cooper, N and Rao, K and Gilmour, K and Hadad, L and Adams, S and Cale, C and Davies, G and Webb, D and Veys, P and Amrolia, P},
doi = {10.1182/blood-2005-05-1819},
journal = {Blood},
pages = {1233--1236},
title = {Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis},
url = {http://dx.doi.org/10.1182/blood-2005-05-1819},
volume = {107},
year = {2006}
}
TY - JOUR
AB - <jats:title>Abstract</jats:title><jats:p>Allogeneic stem cell transplantation (SCT) is curative for hemophagocytic lymphohistiocytosis (HLH). However, patients frequently have significant morbidity before transplantation and there is high transplant-related mortality (TRM). Because first-degree HLH is caused by immune dysregulation, a reduced-intensity conditioned (RIC) regimen might be sufficient for cure while decreasing the TRM. Twelve patients with HLH underwent RIC SCT from a matched family/unrelated or haploidentical donor. Eleven were conditioned with fludarabine/melphalan with additional busulphan for haploidentical grafts. One received fludarabine and 2-Gy total body irradiation (TBI). All patients showed engraftment at a median of 14 days. Nine of 12 (75%) are alive and in complete remission (CR) a median of 30 months (range, 9-73 months) after SCT. Two patients died from pneumonitis and one from hepatic rupture. Four patients developed acute graft-versus-host disease (GVHD) and 3 have chronic GVHD. Three of 9 survivors have mixed chimerism but remain free of disease. In summary, RIC compares favorably to conventional SCT with long-term disease control in surviving patients despite a significant incidence of mixed chimerism.</jats:p>
AU - Cooper,N
AU - Rao,K
AU - Gilmour,K
AU - Hadad,L
AU - Adams,S
AU - Cale,C
AU - Davies,G
AU - Webb,D
AU - Veys,P
AU - Amrolia,P
DO - 10.1182/blood-2005-05-1819
EP - 1236
PY - 2006///
SN - 0006-4971
SP - 1233
TI - Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis
T2 - Blood
UR - http://dx.doi.org/10.1182/blood-2005-05-1819
UR - https://doi.org/10.1182/blood-2005-05-1819
VL - 107
ER -