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Journal articlePospori C, Grey W, Gibson S, et al., 2020,
DYNAMIC REGULATION OF HIERARCHICAL HETEROGENEITY IN ACUTE MYELOID LEUKAEMIA, SERVES AS A TUMOUR IMMUNOEVASION MECHANISM.
, EXPERIMENTAL HEMATOLOGY, Vol: 88, Pages: S75-S75, ISSN: 0301-472X -
Journal articleKumar K, Singanayagam A, Johnston SL, 2020,
Respiratory Virus Infections in Asthma: Research Developments and Therapeutic Advances.
, Acta Med Acad, Vol: 49, Pages: 130-143In this review, we discuss the latest developments in research pertaining to virus-induced asthma exacerbations and consider recent advances in treatment options. Asthma is a chronic disease of the airways that continues to impose a substantial clinical burden worldwide. Asthma exacerbations, characterised by an acute deterioration in respiratory symptoms and airflow obstruction, are associated with significant morbidity and mortality. These episodes are most commonly triggered by respiratory virus infections. The mechanisms underlying the pathogenesis of virus-induced exacerbations have been the focus of extensive biomedical research. Developing a robust understanding of the interplay between respiratory viruses and the host immune response will be critical for developing more efficacious, targeted therapies for exacerbations. CONCLUSION: There has been significant recent progress in our understanding of the mechanisms underlying virus-induced airway inflammation in asthma and these advances will underpin the development of future clinical therapies.
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Journal articleScotney E, Saglani S, 2020,
Diagnosis and Management of Problematic Severe Asthma.
, Acta Med Acad, Vol: 49, Pages: 117-129This review will outline an evidence-based approach for diagnosing and managing children with problematic severe asthma (PSA). Children with PSA have uncontrolled asthma symptoms, despite maximal prescribed asthma treatment. These children have high morbidity and mortality and should be referred for specialist respiratory assessment and management. The first step in the assessment of a child with PSA is confirming the diagnosis of asthma using objective evidence. Following this, an assessment of inhaled corticosteroid adherence and a multi-disciplinary team approach is essential for separating difficult asthma (DA) from severe therapy resistant asthma (STRA). The majority of children have DA which entails uncontrolled asthma symptoms due to underlying modifiable factors including poor treatment adherence, poor inhaler technique, exposure to environmental allergens, co-morbid conditions and psycho-social factors. Approximately 20% of children with PSA have STRA, and have persistent asthma symptoms despite good treatment adherence and correction of modifiable factors. Children with STRA typically have multiple and severe aeroallergen sensitization, eosinophilic airway inflammation and high fraction exhaled nitric oxide (FeNO). Further investigation of children with STRA includes an assessment of systemic steroid responsiveness, this is important for confirming the diagnosis of STRA and guiding the choice of additional treatment. Biologics are an add on (immune targeted) therapy for STRA. The current biologics used in children target the T2 helper (Th2) pathway mediating eosinophilic, allergic asthma. CONCLUSION: Future clinical trials of biologics in children will be essential to help identify childhood specific biomarkers and to decide which biologic is best for which individual child.
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Conference paperSharif H, Fear D, Laisuan W, et al., 2020,
IL-10+T follicular helper cells (CXCR5+PD-1+CD4+TFH10) promote immune tolerance and regulate b cell function following allergen immunotherapy: A proof-of-concept cross-sectional study
, European-Academy-of-Allergology-and-Clinical-Immunology Digital Congress (EAACI), Publisher: WILEY, Pages: 46-46, ISSN: 0105-4538 -
Conference paperZhu R, Sharif H, Laisuan W, et al., 2020,
Establishing a Th2 and Tfh cell exhaustion in vitro model using TCR Signaling to test T cell anergy during immunotherapy
, European-Academy-of-Allergology-and-Clinical-Immunology Digital Congress (EAACI), Publisher: WILEY, Pages: 132-133, ISSN: 0105-4538 -
Conference paperParkin R, Laisuan W, Sanver D, et al., 2020,
Evaluating a method validation to deplete, purify and determine the function of IgG4, IgA1 and IgA2 antibodies induced following sublingual immunotherapy in patients with allergic rhinitis
, European-Academy-of-Allergology-and-Clinical-Immunology Digital Congress (EAACI), Publisher: WILEY, Pages: 131-131, ISSN: 0105-4538 -
Conference paperDuca B, Chong KW, Violan VV, et al., 2020,
Predicting challenge outcome in young people with persistent cow's milk allergy
, European-Academy-of-Allergology-and-Clinical-Immunology Digital Congress (EAACI), Publisher: WILEY, Pages: 299-299, ISSN: 0105-4538 -
Conference paperAlbers GJ, Iwasaki J, Mcerlean P, et al., 2020,
IRF5 regulates airway macrophage metabolic responses to viral challenge
, European-Academy-of-Allergology-and-Clinical-Immunology Digital Congress (EAACI), Publisher: WILEY, Pages: 42-43, ISSN: 0105-4538 -
Conference paperLayhadi JA, Golebski K, Bal SM, et al., 2020,
Grass pollen sublingual immunotherapy drives the generation of functional IL-10-producing innate lymphoid cells that are associated with clinical benefit: An RDBPC study
, European-Academy-of-Allergology-and-Clinical-Immunology Digital Congress (EAACI), Publisher: WILEY, Pages: 45-46, ISSN: 0105-4538 -
Conference paperKumar K, Losa F, Kebadze T, et al., 2020,
Differences in induction of asthma-relevant pro-inflammatory mediators by β2-agonists and muscarinic antagonists in human bronchial epithelial cells
, European-Academy-of-Allergology-and-Clinical-Immunology Digital Congress (EAACI), Publisher: WILEY, Pages: 163-164, ISSN: 0105-4538
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