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  • Journal article
    Waldock J, Olson KE, Christophides GK, 2012,

    <i>Anopheles gambiae</i> Antiviral Immune Response to Systemic O'nyong-nyong Infection

    , PLOS NEGLECTED TROPICAL DISEASES, Vol: 6, ISSN: 1935-2735
    • Cite
    • Citations: 62
  • Journal article
    Ito K, Arko M, Kawaguchi T, Kikusui T, Kuwahara M, Tsubone Het al., 2012,

    Intracerebroventricular administration of taurine impairs learning and memory in rats.

    , Nutr Neurosci, Vol: 15, Pages: 70-77

    OBJECTIVES: Taurine is a semi-essential amino acid widely distributed in the body and we take in it from a wide range of nutritive-tonic drinks to improve health. To date, we have elucidated that oral supplementation of taurine does not affect learning and memory in the rat. However, there are few studies concerning the direct effects of taurine in the brain at the behavior level. In this study, we intracerebroventricularly administered taurine to rats and aimed to elucidate the acute effects on learning and memory using the Morris water maze method. METHODS: Escape latency, swim distance, and distance to zone, which is the integral of the distance between the rats and the platform for every 0.16 seconds, were adopted as parameters of the ability of learning and memory. We also tried to evaluate the effect of intraperitoneal taurine administration. RESULTS: Escape latency, swim distance, and distance to zone were significantly longer in the intracerebroventricularly taurine-administered rats than in the saline-administered rats. Mean swimming velocity was comparable between these two groups, although the physical performance was improved by taurine administration. Probe trials showed that the manner of the rats in finding the platform was comparable. In contrast, no significant differences were found between the intraperitoneally taurine-administered rats and the saline-administered rats. DISCUSSION: These results indicate that taurine administered directly into the brain ventricle suppresses and delays the ability of learning and memory in rats. In contrast, it is implied that taurine administered peripherally was not involved in learning and memory.
  • Journal article
    Gleeson MP, Modi S, Bender A, Robinson RLM, Kirchmair J, Promkatkaew M, Hannongbua S, Glen RCet al., 2012,

    The Challenges Involved in Modeling Toxicity Data <i>In Silico</i>: A Review

    , CURRENT PHARMACEUTICAL DESIGN, Vol: 18, Pages: 1266-1291, ISSN: 1381-6128
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    • Citations: 73
  • Journal article
    Hewson CA, Haas JJ, Bartlett NW, Message SD, Laza-Stanca V, Kebadze T, Caramori G, Zhu J, Edbrooke R, Stanciu LA, Kon OM, Papi A, Jeffery PK, Edwards MR, Johnston SLet al., 2012,

    Rhinovirus induces MUC5AC in a human infection model and <i>in vitro</i> <i>via</i> NF-κB and EGFR pathways (vol 36, pg 1425, 2010)

    , EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 793-793, ISSN: 0903-1936
  • Journal article
    Kirchmair J, Williamson MJ, Tyzack JD, Tan L, Bond PJ, Bender A, Glen RCet al., 2012,

    Computational Prediction of Metabolism: Sites, Products, SAR, P450 Enzyme Dynamics, and Mechanisms

    , JOURNAL OF CHEMICAL INFORMATION AND MODELING, Vol: 52, Pages: 617-648, ISSN: 1549-9596
  • Journal article
    Mehta P, Patel L, Roncaroli F, Pickering MC, Brand Aet al., 2012,

    Painful myositis in the anti-synthetase syndrome with anti-PL12 antibodies

    , RHEUMATOLOGY INTERNATIONAL, Vol: 32, Pages: 825-827, ISSN: 0172-8172
  • Journal article
    Harris J, Ibrahim H, Amen F, Karadimitris A, Naresh KN, Macdonald DHet al., 2012,

    Cellular (FLICE) like inhibitory protein (cFLIP) expression in diffuse large B-cell lymphoma identifies a poor prognostic subset, but fails to predict the molecular subtype

    , HEMATOLOGICAL ONCOLOGY, Vol: 30, Pages: 8-12, ISSN: 0278-0232
  • Journal article
    Koarai A, Traves SL, Fenwick PS, Brown SM, Chana KK, Russell RE, Nicholson AG, Barnes PJ, Donnelly LEet al., 2012,

    Expression of muscarinic receptors by human macrophages.

    , Eur Respir J, Vol: 39, Pages: 698-704

    Macrophages increase in number and are highly activated in chronic obstructive pulmonary disease (COPD). Muscarinic receptor antagonists inhibit acetylcholine-stimulated release of neutrophilic chemoattractants, suggesting that acetylcholine may regulate macrophage responses. Therefore, expression and function of components of the non-neuronal cholinergic system in monocyte-macrophage cells was investigated. RNA was isolated from monocytes, monocyte-derived macrophages (MDMs), lung and alveolar macrophages from nonsmokers, smokers and COPD patients, and expression of the high-affinity choline transporter, choline acetyltransferase, vesicular acetylcholine transporter and muscarinic receptors (M(1)-M(5)) ascertained using real-time PCR. M(2) and M(3) receptor expression was confirmed using immunocytochemistry. Release of interleukin (IL)-8, IL-6 and leukotriene (LT)B(4) were measured by ELISA or EIA. All monocyte-macrophage cells expressed mRNA for components of the non-neuronal cholinergic system. Lung macrophages expressed significantly more M(1) mRNA compared with monocytes, and both lung macrophages and alveolar macrophages expressed the highest levels of M(3) mRNA. Expression of M(2) and M(3) protein was confirmed in MDMs and lung macrophages. Carbachol stimulated release of LTB(4) from lung macrophages (buffer 222.3 ± 75.1 versus carbachol 1,118 ± 622.4 pg · mL(-1); n = 15, p<0.05) but not IL-6 or IL-8. LTB(4) release was attenuated by the M(3) antagonist, 1,1-dimethyl-4-diphenylacetoxypiperidinium iodide (4-DAMP; half maximal effective concentration 5.2 ± 2.2 nM; n = 9). Stimulation of macrophage M(3) receptors promotes release of LTB(4), suggesting that anti-muscarinic agents may be anti-inflammatory.
  • Journal article
    Naji O, Abdallah Y, De Vaate AJB, Smith A, Pexsters A, Stalder C, McIndoe A, Ghaem-Maghami S, Lees C, Brolmann HAM, Huirne JAF, Timmerman D, Bourne Tet al., 2012,

    Standardized approach for imaging and measuring Cesarean section scars using ultrasonography

    , ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 39, Pages: 252-259, ISSN: 0960-7692
  • Journal article
    Zdrenghea MT, Telcian AG, Laza-Stanca V, Bellettato CM, Edwards MR, Nikonova A, Khaitov MR, Azimi N, Groh V, Mallia P, Johnston SL, Stanciu LAet al., 2012,

    RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells

    , EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 712-720, ISSN: 0903-1936
    • Cite
    • Citations: 38

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