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  • Journal article
    Jenkins J, Boyle JJ, Moss VA, McPhaden AR, Lindop GBMet al., 1997,

    Three-dimensional reconstruction of abnormal intramural coronary arteries in human cardiac allograft biopsies

    , JOURNAL OF PATHOLOGY, Vol: 181, Pages: 247-250, ISSN: 0022-3417
  • Journal article
    Franzoso G, Bours V, Azarenko V, Park S, TomitaYamaguchi M, Kanno T, Brown K, Siebenlist Uet al., 1997,

    The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites (vol 12, pg 3893, 1993)

    , EMBO JOURNAL, Vol: 16, Pages: 440-440, ISSN: 0261-4189
  • Journal article
    Bower M, Goodchild K, Evans H, Nelstrop A, Rustin GJSet al., 1997,

    FaFEC: A novel regimen for advanced ovarian cancer

    , INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 7, Pages: 14-17, ISSN: 1048-891X
  • Journal article
    Cookson WO, Moffatt MF, 1997,

    Asthma: an epidemic in the absence of infection?

    , Science, Vol: 275, Pages: 41-42, ISSN: 0036-8075
  • Conference paper
    Busse W, Buist S, Mygind N, Meltzer E, Durham S, Fabbri S, Bousquet J, Holgate S, Bachert Cet al., 1997,

    Epidemiology of rhinitis and asthma

    , Pages: 284-285, ISSN: 0905-9180
    • Cite
    • Citations: 15
  • Conference paper
    Mygind N, Davies R, Canonica GW, Holgate S, Meltzer E, Juniper E, Laitinen L, Durham S, Busse W, Allegra L, Bousquet J, Van Cauwenberge P, Dahlen SE, Barnes P, Fabbri L, Becker A, Bachert Cet al., 1997,

    Rhinitis and asthma: Treatment options

    , Pages: 296-299, ISSN: 0905-9180
  • Journal article
    De Stefano N, Federico A, Mortilla M, Narayanan S, Dotti MT, Dal Pozzo G, Matthews PM, Arnold DIet al., 1997,

    Brain N-acetylaspartate as detected by proton magnetic resonance spectroscopy correlates with central nervous system impairment in patients with white matter disorders

    , Italian Journal of Neurological Sciences, Vol: 18, ISSN: 0392-0461

    The use of magnetic resonance (MR) imaging (MRI) has provided important new insights into the understanding of brain white matter (WM) disorders. However, brain WM abnormalities as detected by conventional MRI do not always give a reliable indication of the severity of the patients' clinical status. Proton MR Spectroscopy (MRS) has demonstrated decreases in N-Acetylaspartate (NAA) in the brains of patients with different brain WM disorders. NAA, a putative index of axonal damage or loss, has shown a strong correlation with the degree of disability in patients with multiple sclerosis. In this study, we used single voxel proton MRS for assessing brain NAA in 13 patients affected by 13 different pathologies involving the brain white matter. Results showed that brain NAA to creatine ratio correlated strongly with patients' central nervous system impairment (measured using the Functional Status Scale) (r= -0.77, p<0.003). hi contrast, a strong relationship was not found between brain abnormalities detected by conventional MRI and patients' clinical status. Our study suggests that the axonal damage that leads to decreases in NAA can be independent of the degree of white matter abnormalities appearing on conventional MRI and may represent a more proximate cause of functional impairment in different brain WM diseases.
  • Conference paper
    Mudway IS, Tetley TD, Charalambous K, Witherden IR, Kelly FJet al., 1997,

    Ozone-exposed respiratory tract lining fluid-mediated toxicity in lung macrophages and epithelial type II cells

    , ISSN: 0954-6111
  • Conference paper
    Van Cauwenberge P, Holgate S, Bousquet J, Durham S, Dahlen SE, Bachert C, Mygind N, Barnes P, Busse W, Becker Aet al., 1997,

    Diagnosis in rhinitis coexisting with asthma

    , Pages: 288-291, ISSN: 0905-9180
    • Cite
    • Citations: 10
  • Journal article
    Milner R, Anderson HJ, Rippon RF, Mckay JS, Franklin RJM, Marchionni MA, Reynolds R, Ffrench-Constant Cet al., 1997,

    Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration

    , GLIA, Vol: 19, Pages: 85-90, ISSN: 0894-1491

    We have examined the effects of the mitogenic growth factors platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and glial growth factor-2 (GGF-2) on oligodendrocyte precursor migration. In an agarose drop migration assay PDGF and bFGF stimulated migration while GGF-2 had no effect. The migration-enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF, confirming that this effect is direct and not mediated via upregulation of PDGF receptors. Based on our results, we propose a model in which the differing effects of PDGF and GGF-2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axons to be myelinated during development.

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