Results
- Showing results for:
- Reset all filters
Search results
-
Journal articleCunnea P, Curry EW, Christie EL, et al., 2023,
Spatial and temporal intra-tumoral heterogeneity in advanced HGSOC: implications for surgical and clinical outcomes
, Cell Reports Medicine, Vol: 4, Pages: 1-20, ISSN: 2666-3791Limited evidence exists on the impact of spatial and temporal heterogeneity of high-grade serous ovarian cancer (HGSOC) on tumor evolution, clinical outcomes, and surgical operability. We perform systematic multi-site tumor mapping at presentation and matched relapse from 49 high-tumor-burden patients, operated up front. From SNP array-derived copy-number data, we categorize dendrograms representing tumor clonal evolution as sympodial or dichotomous, noting most chemo-resistant patients favor simpler sympodial evolution. Three distinct tumor evolutionary patterns from primary to relapse are identified, demonstrating recurrent disease may emerge from pre-existing or newly detected clones. Crucially, we identify spatial heterogeneity for clinically actionable homologous recombination deficiency scores and for poor prognosis biomarkers CCNE1 and MYC. Copy-number signature, phenotypic, proteomic, and proliferative-index heterogeneity further highlight HGSOC complexity. This study explores HGSOC evolution and dissemination across space and time, its impact on optimal surgical cytoreductive effort and clinical outcomes, and its consequences for clinical decision-making.
-
Journal articleBanerjee J, McLister A, Gourin B, et al., 2023,
Tributyrin ester-impregnated pH strips for confirming neonatal feeding tube placement: a diagnostic test accuracy study
, Archives of Disease in Childhood: Fetal and Neonatal Edition, Vol: 108, Pages: 433-434, ISSN: 1359-2998 -
Journal articleAtchison C, Whitaker M, Donnelly C, et al., 2023,
Characteristics and predictors of persistent symptoms post COVID-19 in children and young people: a large community cross-sectional study in England
, Archives of Disease in Childhood, Vol: 108, ISSN: 0003-9888Objective: To estimate the prevalence of, and associated risk factors for, persistent symptoms post-COVID-19 among children aged 5–17 years in England.Design: Serial cross-sectional study.Setting: Rounds 10–19 (March 2021 to March 2022) of the REal-time Assessment of Community Transmission-1 study (monthly cross-sectional surveys of random samples of the population in England).Study population: Children aged 5–17 years in the community.Predictors: Age, sex, ethnicity, presence of a pre-existing health condition, index of multiple deprivation, COVID-19 vaccination status and dominant UK circulating SARS-CoV-2 variant at time of symptom onset.Main outcome measures: Prevalence of persistent symptoms, reported as those lasting ≥3 months post-COVID-19.Results: Overall, 4.4% (95% CI 3.7 to 5.1) of 3173 5–11 year-olds and 13.3% (95% CI 12.5 to 14.1) of 6886 12–17 year-olds with prior symptomatic infection reported at least one symptom lasting ≥3 months post-COVID-19, of whom 13.5% (95% CI 8.4 to 20.9) and 10.9% (95% CI 9.0 to 13.2), respectively, reported their ability to carry out day-to-day activities was reduced ‘a lot’ due to their symptoms. The most common symptoms among participants with persistent symptoms were persistent coughing (27.4%) and headaches (25.4%) in children aged 5–11 years and loss or change of sense of smell (52.2%) and taste (40.7%) in participants aged 12–17 years. Higher age and having a pre-existing health condition were associated with higher odds of reporting persistent symptoms.Conclusions: One in 23 5–11 year-olds and one in eight 12–17 year-olds post-COVID-19 report persistent symptoms lasting ≥3 months, of which one in nine report a large impact on performing day-to-day activities.
-
Journal articleMilighetti M, Peng Y, Tan C, et al., 2023,
Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection
, iScience, Vol: 26, Pages: 1-20, ISSN: 2589-0042T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of individual T cell clones immediately. In SARS-COV-2 PCR+ individuals, a wave of TCRs strongly but transiently expand, frequently peaking the same week as the first positive PCR test. These expanding TCR CDR3s were enriched for sequences functionally annotated as SARS-COV-2 specific. Epitopes recognized by the expanding TCRs were highly conserved between SARS-COV-2 strains but not with circulating human coronaviruses. Many expanding CDR3s were present at high frequency in pre-pandemic repertoires. Early response TCRs specific for lymphocytic choriomeningitis virus epitopes were also found at high frequency in the preinfection naive repertoire. High-frequency naive precursors may allow the T cell response to respond rapidly during the crucial early phases of acute viral infection.
-
Journal articleZhang Y, Yan AWC, Boelen L, et al., 2023,
KIR-HLA interactions extend human CD8+T cell lifespan in vivo
, JOURNAL OF CLINICAL INVESTIGATION, Vol: 133, ISSN: 0021-9738 -
Journal articleArredondo-Alonso S, Blundell-Hunter G, Fu Z, et al., 2023,
Evolutionary and functional history of the Escherichia coli K1 capsule
, Nature Communications, Vol: 14, Pages: 1-17, ISSN: 2041-1723Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E. coli through its association with severe infections. However, little is known about its distribution, evolution and functions across the E. coli phylogeny, which is fundamental to elucidating its role in the expansion of successful lineages. Using systematic surveys of invasive E. coli isolates, we show that the K1-cps locus is present in a quarter of bloodstream infection isolates and has emerged in at least four different extraintestinal pathogenic E. coli (ExPEC) phylogroups independently in the last 500 years. Phenotypic assessment demonstrates that K1 capsule synthesis enhances E. coli survival in human serum independent of genetic background, and that therapeutic targeting of the K1 capsule re-sensitizes E. coli from distinct genetic backgrounds to human serum. Our study highlights that assessing the evolutionary and functional properties of bacterial virulence factors at population levels is important to better monitor and predict the emergence of virulent clones, and to also inform therapies and preventive medicine to effectively control bacterial infections whilst significantly lowering antibiotic usage.
-
Journal articleMonti L, Di Antonio M, 2023,
G-Quadruplexes as Key Transcriptional Regulators in Neglected Trypanosomatid Parasites
, CHEMBIOCHEM, Vol: 24, ISSN: 1439-4227- Cite
- Citations: 6
-
Journal articleRadzikowska U, Eljaszewicz A, Tan G, et al., 2023,
Author Correction: Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19.
, Nat Commun, Vol: 14 -
Journal articlePinato DJ, Cortellini A, 2023,
Antibiotic Therapy: The Cornerstone of Iatrogenic Resistance to Immune Checkpoint Inhibitors
, JOURNAL OF CLINICAL ONCOLOGY, Vol: 41, Pages: 3089-+, ISSN: 0732-183X- Cite
- Citations: 5
-
Journal articleMonaco A, Barbieri BD, Yilmaz G, et al., 2023,
Degradable glycopolymers for saRNA transfection
, POLYMER CHEMISTRY, Vol: 14, Pages: 2750-2761, ISSN: 1759-9954- Cite
- Citations: 4
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.